How tight junctions might prevent small charged solutes from entering the brain (across the blood-brain barrier) is made clear by our new model of tight junction structure based on a lipidic backbone. Tight junctions in invertebrates also appear to have lipidic backbones though our most recent observations suggest that periodic structures, presumably proteins are intercalated into these backbones. This new work has been submitted for publication, and publications describing completed studies on three-- dimensional organization of the vesicular system in capillaries are appearing this year. Otherwise this project is in abeyance.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Intramural Research (Z01)
Project #
1Z01NS001442-25
Application #
3860746
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
25
Fiscal Year
1991
Total Cost
Indirect Cost
City
State
Country
United States
Zip Code