Sphingolipids containing radioactive isotopes were synthesized and used for metabolic studies and as diagnostic tools in spingolipidases. 14C and 3H labels were introduced by synthetic and semi-synthetic techniques, gas exposure and a new approach: functional group exchange. These techniques were used for the syntheses of radioactive enantimorphic derivatives of sphingolipids. These produces are not metabolizable. Experimentation with these in animals creates """"""""animal models"""""""" for metabolic disease and opens new areas for biomedical studies.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Intramural Research (Z01)
Project #
1Z01NS001457-24
Application #
3901536
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
24
Fiscal Year
1989
Total Cost
Indirect Cost
City
State
Country
United States
Zip Code