A study was made of cerebral blood flow (CBF) in gerbils by Laser doppler velocimetry (LDV). Each animal was subjected to five minute bilateral carotid occlusions each hour for 3 hours. Continuous measurement of CBF was made of the parietal cortex through the cranium. There was excellent consistency and repeatability from gerbil to gerbil. The essential features were: The CBF as revealed by LDV, dropped to zero during ischemia, arose upon release of ischemia to a value slightly above the pre- ischemic value, then declined to a much lower value over the hour before the next occlusion. There was no evidence of an accumulative effect with respect to the ischemia.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Intramural Research (Z01)
Project #
1Z01NS002749-02
Application #
3945333
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
1987
Total Cost
Indirect Cost
City
State
Country
United States
Zip Code