Abstract

The following experiments are in progress: 1. Bioassay in mice of blood component infectivity in a mouse-adapted strain of variant CJD. 2. Bioassay in squirrel monkeys of blood component infectivity in human patients with either sporadic or variant Creutzfeldt-Jakob disease (CJD). 3. Inactivation of scrapie agent under incineration conditions of 600C and 1000C, assaying infectivity in both the ashed residue and vented flu gas. The following experiments are in the planning stage: 1. Inactivation of TSE agents using multiple ultra-high pressure pulsation. 2. Bioassay of total volume inoculations of serial dilutions of hamster-adapted scrapie and/or mouse-adapted CJD to determine if infectivity can be diluted to extinction. 3. Determination of intracellular and surface membrane partitioning of prion protein in circulating blood cells. 4. Use of drug combinations to treat symptomatic CJD in primates. 5. Oral and intracerebral inoculation of chronic wasting disease (CWD) in primates with clinical, neuropathological, and molecular biological studies to characterize the disease in a species closely related to humans.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Intramural Research (Z01)
Project #
1Z01NS002957-06
Application #
6659616
Study Section
(LCNS)
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
National Institute of Neurological Disorders and Stroke
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Artwohl, James; Brown, Patricia; Corning, Brian et al. (2006) Report of the ACLAM Task Force on Rodent Euthanasia. J Am Assoc Lab Anim Sci 45:98-105
Stewart, Eugene L; Brown, Peter J; Bentley, James A et al. (2004) Selection, application, and validation of a set of molecular descriptors for nuclear receptor ligands. Comb Chem High Throughput Screen 7:407-12
Caviness, John N; Brown, Peter (2004) Myoclonus: current concepts and recent advances. Lancet Neurol 3:598-607
Serrien, Deborah J; Brown, Peter (2004) Changes in functional coupling patterns during bimanual task performance. Neuroreport 15:1387-90
Rudestam, Kirsten; Brown, Phil; Zarcadoolas, Christina et al. (2004) Children's asthma experience and the importance of place. Health (London) 8:423-44
Mack, Michael J; Brown, Phillip; Houser, Frank et al. (2004) On-pump versus off-pump coronary artery bypass surgery in a matched sample of women: a comparison of outcomes. Circulation 110:II1-6
Sha, Naijun; Vannucci, Marina; Tadesse, Mahlet G et al. (2004) Bayesian variable selection in multinomial probit models to identify molecular signatures of disease stage. Biometrics 60:812-9
Sikorska, Beata; Waliyy, Anna; Bratosiewicz-Wasik, Jolanta et al. (2004) Fate of myelinated fibres in the optic nerves in experimental Creutzfeldt-Jakob disease in rodents: an ultrastructural study. Folia Neuropathol 42:101-5
Brown, Peter (2004) Action myoclonus-renal failure syndrome: the definitive clinico-pathological description. Brain 127:2151-2
Liberski, Pawel P; Brown, Paul (2004) Kuru: a half-opened window onto the landscape of neurodegenerative diseases. Folia Neuropathol 42 Suppl A:3-14

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