The following experiments are in progress: 1. Bioassay in mice of blood component infectivity in a mouse-adapted strain of variant CJD. 2. Bioassay in squirrel monkeys of blood component infectivity in human patients with either sporadic or variant Creutzfeldt-Jakob disease (CJD). 3. Inactivation of scrapie agent under incineration conditions of 600C and 1000C, assaying infectivity in both the ashed residue and vented flu gas. The following experiments are in the planning stage: 1. Inactivation of TSE agents using multiple ultra-high pressure pulsation. 2. Bioassay of total volume inoculations of serial dilutions of hamster-adapted scrapie and/or mouse-adapted CJD to determine if infectivity can be diluted to extinction. 3. Determination of intracellular and surface membrane partitioning of prion protein in circulating blood cells. 4. Use of drug combinations to treat symptomatic CJD in primates. 5. Oral and intracerebral inoculation of chronic wasting disease (CWD) in primates with clinical, neuropathological, and molecular biological studies to characterize the disease in a species closely related to humans.
| Artwohl, James; Brown, Patricia; Corning, Brian et al. (2006) Report of the ACLAM Task Force on Rodent Euthanasia. J Am Assoc Lab Anim Sci 45:98-105 |
| Rowe, Kevin C; Heske, Edward J; Brown, Patrick W et al. (2004) Surviving the ice: Northern refugia and postglacial colonization. Proc Natl Acad Sci U S A 101:10355-9 |
| McCaffrey, Ramona L; Fawcett, Paul; O'Riordan, Mary et al. (2004) A specific gene expression program triggered by Gram-positive bacteria in the cytosol. Proc Natl Acad Sci U S A 101:11386-91 |
| Sharples, Edward J; Patel, Nimesh; Brown, Paul et al. (2004) Erythropoietin protects the kidney against the injury and dysfunction caused by ischemia-reperfusion. J Am Soc Nephrol 15:2115-24 |
| West, Robert B; Harvell, Jeff; Linn, Sabine C et al. (2004) Apo D in soft tissue tumors: a novel marker for dermatofibrosarcoma protuberans. Am J Surg Pathol 28:1063-9 |
| Gerschlager, Willibald; Munchau, Alexander; Katzenschlager, Regina et al. (2004) Natural history and syndromic associations of orthostatic tremor: a review of 41 patients. Mov Disord 19:788-95 |
| Puffer, Suezann; Torgerson, David J; Sykes, David et al. (2004) Health care costs of women with symptomatic vertebral fractures. Bone 35:383-6 |
| Sikorska, Beata; Liberski, Pawel P; Giraud, Pierric et al. (2004) Autophagy is a part of ultrastructural synaptic pathology in Creutzfeldt-Jakob disease: a brain biopsy study. Int J Biochem Cell Biol 36:2563-73 |
| Brown, Peter; Mazzone, Paolo; Oliviero, Antonio et al. (2004) Effects of stimulation of the subthalamic area on oscillatory pallidal activity in Parkinson's disease. Exp Neurol 188:480-90 |
| Brown, Phil; Zavestoski, Stephen (2004) Social movements in health: an introduction. Sociol Health Illn 26:679-94 |
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