The Laryngeal and Speech Section investigates the control of laryngeal functioning in normal and disordered voice, speech and swallowing. Currently the Section has three projects addressing: 1) the role of sensory functioning in normal and disordered laryngeal control for voice and swallowing; 2) risk factors involved in familial speech and voice disorders; and 3) the use of neuromuscular stimulation to provide integrative control of the pharyngeal component of swallowing. Significant advances were made in the following directions: (1) Role of Sensory Functioning in Voice, Speech and Swallowing. Previously the Section demonstrated that patients with adductor spasmodic dysphonia, a laryngeal dystonia with spasmodic bursts in the thyroarytenoid muscles, had abnormal laryngeal responses to sensory conditioning. This suggested that abnormal modulation of sensorimotor repsonses might account for symptoms in this disorder. In the last year, the Section published a study in abductor spasmodic dysphonia, another form of laryngeal dystonia, demonstrating a similar abnormality in thyroarytenoid muscle responses to sensory stimulation in this disorder. Because the voice symptoms differ between these two forms of laryngeal dystonia, an ongoing study is investigating the muscle activation abnormalities during speech symptoms in abductor spasmodic dysphonia to determine how the pathophysiology of these two forms differ. Two studies were published this year on the neural substrates that may be involved in sensory control of vocalization. The nucleus tractus solitarius (NTS) is the primary termination zone for laryngeal afferents. The immunohistochemical distribution of alpha-amino-3- hydroxy-5-methyl-4-isoxazolepropionate (AMPA)-selective glutamate receptor subunits (GluR1, GluR2/3, GluR4) and the N-methyl-D-aspartate (NMDA) receptor subunit NR1 in the caudal brainstem was investigated by using subunit-specific antibodies. Significant differences were found in the distribution of various receptor subunit types. GluR2/3 was highest in most subnuclei, while GluR1-containing neurons were more frequent than NR1- or GluR4-immunoreactive neurons. GluR1 immunolabeling was particularly high in the interstitial subnucleus, the region of the NTS previously found to be most active during elicitation of the early R1 adductor reflex. The second study examined neuronal activation in the periaquaductal gray (PAG), a midbrain region known to be involved in the generation of vocalization in animals. Two groups were contrasted: those receiving afferent stimulation resulting in the early R1 laryngeal adductor reflex, and control unstimulated animals. The number of neurons expressing Fos, the protein product of an immediate early gene c-fos, was examined in all PAG areas, including the dorsolateral and lateral regions which control vocalization functions. Comparisons between stimulated and control animals demonstrated increased fos expression associated with laryngeal stimulation only in the regions associated with vocalization and not in other PAG regions. How this sensory information normally alters vocalization patterns will be determined next. (2) Risk factors for Familial Voice and Speech Disorders. During the last 3 years, although the Section had recruited families with either adductor or abductor spasmodic dysphonia, only families with abductor spasmodic dysphonia were identified. All of the affected members are female with an earlier age of onset than found in the more common sporadic cases. The DYT1 mutation has been excluded in all of those tested thus far. (3) Development of a Laryngeal Neuroprosthesis for Dysphagia.
The aim i s to develop a neuroprosthesis for the prevention of aspiration in neurological disorders. A study was completed this year demonstrating the feasibility of stimulating the laryngeal muscles to produce dynamic control over laryngeal closure in animals. The implant remained fully functional for 6 months; laryngeal muscle characteristics were not adversely affected by chronic stimulation, and stable control over glottic closure was maintained. The next objective will be to achieve control over laryngeal elevation, similar to that occurring during normal swallowing in humans. - spasmodic dysphonia, voice, speech, swallowing, brainstem, sensorimotor control, familial disorders, neuroprosthesis - Human Subjects

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Intramural Research (Z01)
Project #
1Z01NS002980-01
Application #
6228071
Study Section
Special Emphasis Panel (MNB)
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost
City
State
Country
United States
Zip Code
Lee, Yeongjun; Choi, Jinwoo; Ko, Nak Yong et al. (2017) Probability-Based Recognition Framework for Underwater Landmarks Using Sonar Images †. Sensors (Basel) 17:
Chang, Soo-Eun; Synnestvedt, Anna; Ostuni, John et al. (2010) Similarities in speech and white matter characteristics in idiopathic developmental stuttering and adult-onset stuttering. J Neurolinguistics 23:455-469
Ludlow, Christy L (2009) Treatment for spasmodic dysphonia: limitations of current approaches. Curr Opin Otolaryngol Head Neck Surg 17:160-5
Feng, Xin; Henriquez, Victor M; Walters, Judith R et al. (2009) Effects of dopamine D1 and D2 receptor antagonists on laryngeal neurophysiology in the rat. J Neurophysiol 102:1193-205
Chang, Soo-Eun; Kenney, Mary Kay; Loucks, Torrey M J et al. (2009) Common neural substrates support speech and non-speech vocal tract gestures. Neuroimage 47:314-25
Chang, Soo-Eun; Kenney, Mary Kay; Loucks, Torrey M J et al. (2009) Brain activation abnormalities during speech and non-speech in stuttering speakers. Neuroimage 46:201-12
Lowell, Soren Y; Poletto, Christopher J; Knorr-Chung, Bethany R et al. (2008) Sensory stimulation activates both motor and sensory components of the swallowing system. Neuroimage 42:285-95
Ludlow, Christy L; Adler, Charles H; Berke, Gerald S et al. (2008) Research priorities in spasmodic dysphonia. Otolaryngol Head Neck Surg 139:495-505
Simpson, D M; Blitzer, A; Brashear, A et al. (2008) Assessment: Botulinum neurotoxin for the treatment of movement disorders (an evidence-based review): report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology 70:1699-706
Simonyan, Kristina; Tovar-Moll, Fernanda; Ostuni, John et al. (2008) Focal white matter changes in spasmodic dysphonia: a combined diffusion tensor imaging and neuropathological study. Brain 131:447-59

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