Magnetic Resonance Imaging And Spectroscopy

Duyn, Jozef H.

Abstract

Main research goals include the development of new MRI techniques that eludicate new physiologic contrast mechanisms in human brain with improved sensitivity and resolution. For this purpose, part of the research is aimed at expanding basic knowledge of MRI signal generation. As a result of the research significant technologic advances were made in MRI of human brain. A prototype MRI detector was developed, based on multi-channel array technology, that allows sensitivity, resolution and speed improvement in MRI of human brain. A novel design allows fully independent reception through multiple detector channels, resulting in a 2-3 fold improvement in senstivity, while providing the flexibility to perform accelerated imaging using the recently introduced parallel MRI technology (SENSE). Using the new detector, SENSE technology was developed to perform functional neuroimaging on normal volunteers. Preliminary results show large senstivity and resolution improvements. In addition, technology was developed to improve sensitivity of imaging of perfusion in resting consition and during activation experiments. This technology is currently being combined with the parallel imaging techniques to achieve overall sensitivity improvements of 4-5 fold over conventional techniques. Projects were started to apply the new methodology to investigate somatotopy and retinotopy in human brain.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Neurological Disorders and Stroke (NINDS)
• Type: Intramural Research (Z01)
• Project #: 1Z01NS002990-02
• Application #: 6546851
• Study Section: (LFMI)
• Support Year: 2
• Fiscal Year: 2001

Institution

• Name: National Institute of Neurological Disorders and Stroke
• Country: United States

Publications

van Gelderen, Peter; Jiang, Xu; Duyn, Jeff H (2017) Rapid measurement of brain macromolecular proton fraction with transient saturation transfer MRI. Magn Reson Med 77:2174-2185

Duyn, Jeff (2011) Spontaneous fMRI activity during resting wakefulness and sleep. Prog Brain Res 193:295-305

Li, Tie-Qiang; Yao, Bing; van Gelderen, Peter et al. (2009) Characterization of T(2)* heterogeneity in human brain white matter. Magn Reson Med 62:1652-7

Bianciardi, Marta; Fukunaga, Masaki; van Gelderen, Peter et al. (2009) Sources of functional magnetic resonance imaging signal fluctuations in the human brain at rest: a 7 T study. Magn Reson Imaging 27:1019-29

Horovitz, Silvina G; Fukunaga, Masaki; de Zwart, Jacco A et al. (2008) Low frequency BOLD fluctuations during resting wakefulness and light sleep: a simultaneous EEG-fMRI study. Hum Brain Mapp 29:671-82

Duyn, Jeff H; van Gelderen, Peter; Li, Tie-Qiang et al. (2007) High-field MRI of brain cortical substructure based on signal phase. Proc Natl Acad Sci U S A 104:11796-801

Shmueli, Karin; van Gelderen, Peter; de Zwart, Jacco A et al. (2007) Low-frequency fluctuations in the cardiac rate as a source of variance in the resting-state fMRI BOLD signal. Neuroimage 38:306-20

van Gelderen, P; de Zwart, J A; Starewicz, P et al. (2007) Real-time shimming to compensate for respiration-induced B0 fluctuations. Magn Reson Med 57:362-8

Silva, Afonso C; Koretsky, Alan P; Duyn, Jeff H (2007) Functional MRI impulse response for BOLD and CBV contrast in rat somatosensory cortex. Magn Reson Med 57:1110-8

Deckers, Roel H R; van Gelderen, Peter; Ries, Mario et al. (2006) An adaptive filter for suppression of cardiac and respiratory noise in MRI time series data. Neuroimage 33:1072-81