Improvement is sought for an approach to the delivery of macromolecular agents to solid tumors and other diseased tissue. The approach, which has been termed """"""""convection-enhanced delivery,"""""""" is one of delivery to target tissue interstitium by infusion. Infused agents are carried through the interstitium by the bulk flow of the infusate solution to achieve more rapid spatial spread than would occur by diffusion. Typically, such infusions have been limited to submicroliter per minute flow rates by the occurrence of undesired leakage along the track of the infusion cannula. This limitation may be overcome by cannula modification to provide a greater surface area for entry of the infusate into the tissue. Various cannula designs are being investigated.

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
Intramural Research (Z01)
Project #
1Z01OD011031-04
Application #
6837005
Study Section
(BEPS)
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
2003
Total Cost
Indirect Cost
Name
Office of the Director, NIH
Department
Type
DUNS #
City
State
Country
United States
Zip Code