The intent of this project is to study the corticotropin releasing hormone (CRH) mRNA distribution in immune challenged lewis and fischer rats. Abnormalities in central secretion of CRH have been correlated with the pathophysiology of several diseases such as arthritis, allergic encephalomyelitis, lupus erythematosus, major depression, anorexia nervosa, Alzheimer's disease, and chronic fatigue syndrome. Hypothalamic CRH inhibits vegetative behaviors that are thought of as adaptive to stressful situations such as feeding, growth, reproduction, and sexual behavior. The differential distributions of CRH receptors are mapped in three-dimension in the brain providing more insight of the mechanism how the difference in hypothalamic CRH expression and regulation has a functional role in regulating the inflammatory response as suggested by genetic linkage analysis.

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
Intramural Research (Z01)
Project #
1Z01OD011073-01
Application #
6685031
Study Section
(BEPS)
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2002
Total Cost
Indirect Cost
Name
Office of the Director, NIH
Department
Type
DUNS #
City
State
Country
United States
Zip Code