Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Intramural Research (Z01)
Project #
1Z01SC000173-06
Application #
6163235
Study Section
Special Emphasis Panel (M)
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
1997
Total Cost
Indirect Cost
Name
National Cancer Institute Division of Clinical Sciences
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Martinez, Alfredo; Zudaire, Enrique; Julian, Miguel et al. (2005) Gastrin-releasing peptide (GRP) induces angiogenesis and the specific GRP blocker 77427 inhibits tumor growth in vitro and in vivo. Oncogene 24:4106-13
Julian, Miguel; Cacho, Monica; Garcia, Mario A et al. (2005) Adrenomedullin: a new target for the design of small molecule modulators with promising pharmacological activities. Eur J Med Chem 40:737-50
Cuesta, Natalia; Martinez, Alfredo; Cuttitta, Frank et al. (2005) Identification of adrenomedullin in avian type II pneumocytes: increased expression after exposure to air pollutants. J Histochem Cytochem 53:773-80
Zudaire, Enrique; Cuesta, Natalia; Martinez, Alfredo et al. (2005) Characterization of adrenomedullin in birds. Gen Comp Endocrinol 143:10-20
Martinez, Alfredo; Zudaire, Enrique; Portal-Nunez, Sergio et al. (2004) Proadrenomedullin NH2-terminal 20 peptide is a potent angiogenic factor, and its inhibition results in reduction of tumor growth. Cancer Res 64:6489-94
Martinez, Alfredo; Oh, Hae-Ryong; Unsworth, Edward J et al. (2004) Matrix metalloproteinase-2 cleavage of adrenomedullin produces a vasoconstrictor out of a vasodilator. Biochem J 383:413-8
Martinez, Alfredo; Julian, Miguel; Bregonzio, Claudia et al. (2004) Identification of vasoactive nonpeptidic positive and negative modulators of adrenomedullin using a neutralizing antibody-based screening strategy. Endocrinology 145:3858-65
Zudaire, Enrique; Martinez, Alfredo; Ozbun, Laurent L et al. (2004) Characterization of adrenomedullin in non-human primates. Biochem Biophys Res Commun 321:859-69
Ajona, Daniel; Castano, Zafira; Garayoa, Mercedes et al. (2004) Expression of complement factor H by lung cancer cells: effects on the activation of the alternative pathway of complement. Cancer Res 64:6310-8
Macpherson, Gordon R; Ng, Sylvia S W; Forbes, Siiri L et al. (2003) Anti-angiogenic activity of human endostatin is HIF-1-independent in vitro and sensitive to timing of treatment in a human saphenous vein assay. Mol Cancer Ther 2:845-54

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