Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Intramural Research (Z01)
Project #
1Z01SC009179-09
Application #
6163341
Study Section
Special Emphasis Panel (LP)
Project Start
Project End
Budget Start
Budget End
Support Year
9
Fiscal Year
1997
Total Cost
Indirect Cost
Name
National Cancer Institute Division of Clinical Sciences
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Kim, Soo Hyeon; Cho, Young-Rak; Kim, Hyeon-Ju et al. (2012) Antagonism of VEGF-A-induced increase in vascular permeability by an integrin ?3?1-Shp-1-cAMP/PKA pathway. Blood 120:4892-902
Guedez, Liliana; Jensen-Taubman, Sandra; Bourboulia, Dimitra et al. (2012) TIMP-2 targets tumor-associated myeloid suppressor cells with effects in cancer immune dysfunction and angiogenesis. J Immunother 35:502-12
Seo, Dong-Wan; Saxinger, W Carl; Guedez, Liliana et al. (2011) An integrin-binding N-terminal peptide region of TIMP-2 retains potent angio-inhibitory and anti-tumorigenic activity in vivo. Peptides 32:1840-8
Lee, Seo-Jin; Tsang, Patricia S; Diaz, Tere M et al. (2010) TIMP-2 modulates VEGFR-2 phosphorylation and enhances phosphodiesterase activity in endothelial cells. Lab Invest 90:374-82
Bourboulia, Dimitra; Stetler-Stevenson, William G (2010) Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs): Positive and negative regulators in tumor cell adhesion. Semin Cancer Biol 20:161-8
Alper, Ozge; Stetler-Stevenson, William G; Harris, Lyndsay N et al. (2009) Novel anti-filamin-A antibody detects a secreted variant of filamin-A in plasma from patients with breast carcinoma and high-grade astrocytoma. Cancer Sci 100:1748-56
Lee, Hongsik; Lim, Chaeseung; Lee, Jungeun et al. (2008) TGF-beta signaling preserves RECK expression in activated pancreatic stellate cells. J Cell Biochem 104:1065-74
Stetler-Stevenson, William G (2008) Tissue inhibitors of metalloproteinases in cell signaling: metalloproteinase-independent biological activities. Sci Signal 1:re6
Stetler-Stevenson, William G (2008) The tumor microenvironment: regulation by MMP-independent effects of tissue inhibitor of metalloproteinases-2. Cancer Metastasis Rev 27:57-66
Seo, Dong-Wan; Kim, Soo Hyeon; Eom, Seok-Hyun et al. (2008) TIMP-2 disrupts FGF-2-induced downstream signaling pathways. Microvasc Res 76:145-51

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