Abstract

Transmission electron microscopy (EM) is used as an adjunct procedure in the diagnosis of a wide range of neoplastic and non neoplastic diseases and can be extremely useful in well chosen diagnostic dilemmas. The service is regularly inspected and certified by CAP, and is the only diagnostic CAP-certified EM service on NIH campus. A total of 105 cases were processed last year, consisting of 135 specimens and 282 blocks. In addition, 110 research specimens were processed and evaluated to support experimental studies of various NCI/NIH investigators. The diagnostic specimens that are submitted to our service for ultrastructural evaluation are from patients treated in NCI/NIH protocols and are diagnostically and scientifically challenging. Due to the nature of the NCI protocols, we are often the first to describe the unusual and unique ultrastructural findings of a tumor or disease, or the outcome of experimental treatments.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Intramural Research (Z01)
Project #
1Z01SC009394-15
Application #
7735393
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
15
Fiscal Year
2008
Total Cost
$369,250
Indirect Cost

  Institution

Name
National Cancer Institute Division of Clinical Sciences
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Martin-Manso, Gema; Galli, Susana; Ridnour, Lisa A et al. (2008) Thrombospondin 1 promotes tumor macrophage recruitment and enhances tumor cell cytotoxicity of differentiated U937 cells. Cancer Res 68:7090-9
Lodish, Maya B; Powell, Anathea C; Abu-Asab, Mones et al. (2008) Insulinoma and gastrinoma syndromes from a single intrapancreatic neuroendocrine tumor. J Clin Endocrinol Metab 93:1123-8
Lee, In Hye; Cao, Liu; Mostoslavsky, Raul et al. (2008) A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. Proc Natl Acad Sci U S A 105:3374-9
Yang, Youfeng; Padilla-Nash, Hesed M; Vira, Manish A et al. (2008) The UOK 257 cell line: a novel model for studies of the human Birt-Hogg-Dube gene pathway. Cancer Genet Cytogenet 180:100-9
Valencia, Julio C; Rouzaud, Francois; Julien, Sylvain et al. (2007) Sialylated core 1 O-glycans influence the sorting of Pmel17/gp100 and determine its capacity to form fibrils. J Biol Chem 282:11266-80
Alesci, Salvatore; Perera, Shiromi M; Lai, Edwin W et al. (2007) Adenoviral gene transfer in bovine adrenomedullary and murine pheochromocytoma cells: potential clinical and therapeutic relevance. Endocrinology 148:3900-7
Isenberg, Jeff S; Hyodo, Fuminori; Matsumoto, Ken-Ichiro et al. (2007) Thrombospondin-1 limits ischemic tissue survival by inhibiting nitric oxide-mediated vascular smooth muscle relaxation. Blood 109:1945-52
Steel, Jason C; Cavanagh, Heather M A; Burton, Mark A et al. (2007) Increased tumor localization and reduced immune response to adenoviral vector formulated with the liposome DDAB/DOPE. Eur J Pharm Sci 30:398-405
Isenberg, Jeff S; Romeo, Martin J; Abu-Asab, Mones et al. (2007) Increasing survival of ischemic tissue by targeting CD47. Circ Res 100:712-20
Ge, Yun; Montano, Idalia; Rustici, Gabriella et al. (2006) Selective leukemic-cell killing by a novel functional class of thalidomide analogs. Blood 108:4126-35

Showing the most recent 10 out of 23 publications