Regulation of the Fas Receptor and Its Ligand in Pediatric Tumors

Tsokos, M.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Intramural Research (Z01)
• Project #: 1Z01SC010058-02
• Application #: 6163373
• Study Section: Special Emphasis Panel (LP)
• Support Year: 2
• Fiscal Year: 1997

Institution

• Name: National Cancer Institute Division of Clinical Sciences
• Country: United States

Publications

Lee, Betty; Galli, Susanna; Tsokos, Maria (2007) Sensitive Ewing sarcoma and neuroblastoma cell lines have increased levels of BAD expression and decreased levels of BAR expression compared to resistant cell lines. Cancer Lett 247:110-4

Lissat, Andrej; Vraetz, Thomas; Tsokos, Maria et al. (2007) Interferon-gamma sensitizes resistant Ewing's sarcoma cells to tumor necrosis factor apoptosis-inducing ligand-induced apoptosis by up-regulation of caspase-8 without altering chemosensitivity. Am J Pathol 170:1917-30

Merchant, Melinda S; Yang, Xuezhong; Melchionda, Fraia et al. (2004) Interferon gamma enhances the effectiveness of tumor necrosis factor-related apoptosis-inducing ligand receptor agonists in a xenograft model of Ewing's sarcoma. Cancer Res 64:8349-56

Tsokos, George C; Tsokos, Maria (2003) The TRAIL to arthritis. J Clin Invest 112:1315-7

Yang, Xuezhong; Merchant, Melinda S; Romero, Maria E et al. (2003) Induction of caspase 8 by interferon gamma renders some neuroblastoma (NB) cells sensitive to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) but reveals that a lack of membrane TR1/TR2 also contributes to TRAIL resistance in NB. Cancer Res 63:1122-9

Mitsiades, N; Poulaki, V; Leone, A et al. (1999) Fas-mediated apoptosis in Ewing's sarcoma cell lines by metalloproteinase inhibitors. J Natl Cancer Inst 91:1678-84