Our group is principally concerned with the molecular biology of HIV pathogenesis, especially the pathogenesis of pediatric HIV disease. The course of HIV disease in pediatric patients differs substantially from the course of disease in adults. Because some of the factors that help modulate the course of HIV disease depend on the host and host cells, we are therefore particularly interested in trying to understand the involvement of host cell factors in HIV replication and the effect of HIV infection on the host cell. The hypothesis guiding much of our work holds that there is one set of cellular conditions that is ideal for normal cellular growth and replication, that another set of conditions is ideal for viral replication, and that viruses (particularly HIV) have evolved ways of altering their host cells to enhance viral replication.

National Institute of Health (NIH)
Division of Clinical Sciences - NCI (NCI)
Intramural Research (Z01)
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Clinical Sciences
United States
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Yoshizuka, Naoto; Yoshizuka-Chadani, Yuko; Krishnan, Vyjayanthi et al. (2005) Human immunodeficiency virus type 1 Vpr-dependent cell cycle arrest through a mitogen-activated protein kinase signal transduction pathway. J Virol 79:11366-81
Taylor, Perdita; Worrell, Carol; Steinberg, Seth M et al. (2004) Natural history of lipid abnormalities and fat redistribution among human immunodeficiency virus-infected children receiving long-term, protease inhibitor-containing, highly active antiretroviral therapy regimens. Pediatrics 114:e235-42
Krishnan, Vyjayanthi; Zeichner, Steven L (2004) Host cell gene expression during human immunodeficiency virus type 1 latency and reactivation and effects of targeting genes that are differentially expressed in viral latency. J Virol 78:9458-73
Bentley, K; Deacon, N; Sonza, S et al. (2004) Mutational analysis of the HIV-1 LTR as a promoter of negative sense transcription. Arch Virol 149:2277-94
Hazra, Rohan; Balis, Frank M; Tullio, Antonella N et al. (2004) Single-dose and steady-state pharmacokinetics of tenofovir disoproxil fumarate in human immunodeficiency virus-infected children. Antimicrob Agents Chemother 48:124-9
Suscovich, Todd J; Paulose-Murphy, Mini; Harlow, Jason D et al. (2004) Defective immune function of primary effusion lymphoma cells is associated with distinct KSHV gene expression profiles. Leuk Lymphoma 45:1223-38
Tamula, Mary Anne Toledo; Wolters, Pamela L; Walsek, Claire et al. (2003) Cognitive decline with immunologic and virologic stability in four children with human immunodeficiency virus disease. Pediatrics 112:679-84
Nakamura, Hiroyuki; Lu, Michael; Gwack, Yousang et al. (2003) Global changes in Kaposi's sarcoma-associated virus gene expression patterns following expression of a tetracycline-inducible Rta transactivator. J Virol 77:4205-20
Shibata, R; Feng, Y R; Gee, D et al. (1999) Telomere dynamics in monkeys: increased cell turnover in macaques infected with chimeric simian-human immunodeficiency viruses. J Med Primatol 28:1-10
Feng, Y R; Biggar, R J; Gee, D et al. (1999) Long-term telomere dynamics: modest increase of cell turnover in HIV-infected individuals followed for up to 14 years. Pathobiology 67:34-8

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