Abstract

The goal of this project is to study the interaction of radiotherapy and angiogenesis inhibitors. The majority of inhibitors have been previously shown to be synergistic with radiotherapy. We will examine these effects in vivo and in vitro at the molecular level.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Division of Clinical Sciences - NCI (NCI)
Type
Intramural Research (Z01)
Project #
1Z01SC010373-02
Application #
6758402
Study Section
(RO)
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
Clinical Sciences
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Tandle, Anita; Camphausen, Kevin (2016) Mitotic Protein Kinase 1: Role in Spindle Assembly Checkpoint Revisited. J Cancer Clin Trials 1:
Sharp, Hadley J; Wansley, Elizabeth K; Garnett, Charlie T et al. (2007) Synergistic antitumor activity of immune strategies combined with radiation. Front Biosci 12:4900-10
Camphausen, Kevin; Tofilon, Philip J (2007) Inhibition of Hsp90: a multitarget approach to radiosensitization. Clin Cancer Res 13:4326-30
Seggewiss, Ruth; Lore, Karin; Guenaga, F Javier et al. (2007) Keratinocyte growth factor augments immune reconstitution after autologous hematopoietic progenitor cell transplantation in rhesus macaques. Blood 110:441-9
de la Pena, Lorena; Burgan, William E; Carter, Donna J et al. (2006) Inhibition of Akt by the alkylphospholipid perifosine does not enhance the radiosensitivity of human glioma cells. Mol Cancer Ther 5:1504-10
Reits, Eric A; Hodge, James W; Herberts, Carla A et al. (2006) Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy. J Exp Med 203:1259-71
Barker, Christopher A; Burgan, William E; Carter, Donna J et al. (2006) In vitro and in vivo radiosensitization induced by the ribonucleotide reductase inhibitor Triapine (3-aminopyridine-2-carboxaldehyde-thiosemicarbazone). Clin Cancer Res 12:2912-8
Cerna, David; Camphausen, Kevin; Tofilon, Philip J (2006) Histone deacetylation as a target for radiosensitization. Curr Top Dev Biol 73:173-204
Hassan, Raffit; Williams-Gould, Juanita; Steinberg, Seth M et al. (2006) Tumor-directed radiation and the immunotoxin SS1P in the treatment of mesothelin-expressing tumor xenografts. Clin Cancer Res 12:4983-8
Lu, Xing; de la Pena, Lorena; Barker, Christopher et al. (2006) Radiation-induced changes in gene expression involve recruitment of existing messenger RNAs to and away from polysomes. Cancer Res 66:1052-61

Showing the most recent 10 out of 19 publications