Abstract

The goal of this project is to study the interaction of radiotherapy and molecularly targeted agents. This project focuses on expanding drugs that show synergy in vitro to the in vivo setting, with the goal of translation to the clinic. In the past year we have initiated a clinical trial with a class of agents discovered in my laboratory to be potent radiation sensitizers (histone deactylase inhibitors, HDACi). We have accrued our first 9 patients. We will initiate a brain met study and a spine met study this year.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Intramural Research (Z01)
Project #
1Z01SC010373-08
Application #
7735417
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
8
Fiscal Year
2008
Total Cost
$841,556
Indirect Cost

  Institution

Name
National Cancer Institute Division of Clinical Sciences
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Tandle, Anita; Camphausen, Kevin (2016) Mitotic Protein Kinase 1: Role in Spindle Assembly Checkpoint Revisited. J Cancer Clin Trials 1:
Sharp, Hadley J; Wansley, Elizabeth K; Garnett, Charlie T et al. (2007) Synergistic antitumor activity of immune strategies combined with radiation. Front Biosci 12:4900-10
Camphausen, Kevin; Tofilon, Philip J (2007) Inhibition of Hsp90: a multitarget approach to radiosensitization. Clin Cancer Res 13:4326-30
Seggewiss, Ruth; Lore, Karin; Guenaga, F Javier et al. (2007) Keratinocyte growth factor augments immune reconstitution after autologous hematopoietic progenitor cell transplantation in rhesus macaques. Blood 110:441-9
de la Pena, Lorena; Burgan, William E; Carter, Donna J et al. (2006) Inhibition of Akt by the alkylphospholipid perifosine does not enhance the radiosensitivity of human glioma cells. Mol Cancer Ther 5:1504-10
Reits, Eric A; Hodge, James W; Herberts, Carla A et al. (2006) Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy. J Exp Med 203:1259-71
Barker, Christopher A; Burgan, William E; Carter, Donna J et al. (2006) In vitro and in vivo radiosensitization induced by the ribonucleotide reductase inhibitor Triapine (3-aminopyridine-2-carboxaldehyde-thiosemicarbazone). Clin Cancer Res 12:2912-8
Cerna, David; Camphausen, Kevin; Tofilon, Philip J (2006) Histone deacetylation as a target for radiosensitization. Curr Top Dev Biol 73:173-204
Hassan, Raffit; Williams-Gould, Juanita; Steinberg, Seth M et al. (2006) Tumor-directed radiation and the immunotoxin SS1P in the treatment of mesothelin-expressing tumor xenografts. Clin Cancer Res 12:4983-8
Lu, Xing; de la Pena, Lorena; Barker, Christopher et al. (2006) Radiation-induced changes in gene expression involve recruitment of existing messenger RNAs to and away from polysomes. Cancer Res 66:1052-61

Showing the most recent 10 out of 19 publications