Abstract

Section on Clinical Genomics and Experimental Therapeutics (SCGET) 1. Conducts pre-clinical studies and translational clinical studies with focus on genomics and epigenetics related to the pathophysiology and treatment of alcohol use disorders and addictions. 2. Pre-clinical work focuses on identifying molecular mechanisms involved in addictions, utilizing a wide array of methods including human population genetics, genome wide genotyping approaches, next-generation DNA and RNA sequencing, and epigenetic/proteomic profiling. 3. Findings are translated into human clinical studies using molecular biomarker, pharmacogenetic, epigenetic and functional imaging genetic approaches. 4. Clinical studies include early phase 1 / phase 2 proof-of-concept studies of experimental novel therapeutics guided by molecular biomarker profiling.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAAA000242-01
Application #
9155431
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2015
Total Cost
Indirect Cost

  Institution

Name
Alcohol Abuse and Alcoholism
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Muench, Christine; Schwandt, Melanie; Jung, Jeesun et al. (2018) The major depressive disorder GWAS-supported variant rs10514299 in TMEM161B-MEF2C predicts putamen activation during reward processing in alcohol dependence. Transl Psychiatry 8:131
Mauro, Kelsey L; Helton, Sarah G; Rosoff, Dan B et al. (2018) Association Analysis Between Genetic Variation in GATA Binding Protein 4 (GATA4) and Alcohol Use Disorder. Alcohol Alcohol 53:361-367
Wiers, Corinde E; Lohoff, Falk W; Lee, Jisoo et al. (2018) Methylation of the dopamine transporter gene in blood is associated with striatal dopamine transporter availability in ADHD: A preliminary study. Eur J Neurosci 48:1884-1895
Negorev, Dmitri; Beier, Ulf H; Zhang, Tianyi et al. (2018) Human neutrophils can mimic myeloid-derived suppressor cells (PMN-MDSC) and suppress microbead or lectin-induced T cell proliferation through artefactual mechanisms. Sci Rep 8:3135
Lohoff, Falk W (2018) Lipid-Lowering Drug Effects Beyond the Cardiovascular System: Relevance for Neuropsychiatric Disorders. Int J Neuropsychopharmacol 21:1076-1078
Lee, Ji Soo; Sorcher, Jill L; Rosen, Allison D et al. (2018) Genetic Association and Expression Analyses of the Phosphatidylinositol-4-Phosphate 5-Kinase (PIP5K1C) Gene in Alcohol Use Disorder-Relevance for Pain Signaling and Alcohol Use. Alcohol Clin Exp Res 42:1034-1043
Charlet, Katrin; Rosenthal, Annika; Lohoff, Falk W et al. (2018) Imaging resilience and recovery in alcohol dependence. Addiction 113:1933-1950
Muench, Christine; Wiers, Corinde E; Cortes, Carlos R et al. (2018) Dopamine Transporter Gene Methylation is Associated with Nucleus Accumbens Activation During Reward Processing in Healthy but not Alcohol-Dependent Individuals. Alcohol Clin Exp Res 42:21-31
Lohoff, F W; Sorcher, J L; Rosen, A D et al. (2018) Methylomic profiling and replication implicates deregulation of PCSK9 in alcohol use disorder. Mol Psychiatry 23:1-11
Zhu, Xi; Du, Xiaofei; Kerich, Mike et al. (2018) Random forest based classification of alcohol dependence patients and healthy controls using resting state MRI. Neurosci Lett 676:27-33

Showing the most recent 10 out of 16 publications