DNA damage accumulates with age and how this damage promotes aging is of great interest. While it's well established that mutations in some DNA repair genes predispose individuals to cancer and aging, its also possible that mutations in DNA repair genes alters the capacity of individuals to recover from acute bouts of oxidative stress, ie stroke, heart attacks and other ischemic events. Thus, we are screening Base Excision Repair genes for single nucleotide polymorphisms within the BLSA sample populations as a means to begin to address this problem. Our initial screen identified three potentially interesting SNPs. Moving forward we will replicate our findings using meta-analysis on new cohorts. Results from these studies are expected to identify which BER genes play a greater role than others in aging and health outcomes.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAAG000729-23
Application #
9349273
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
23
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Aging
Department
Type
DUNS #
City
State
Country
Zip Code
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