We seek to explore the relationship between mitochondrial dysfunction and accumulation of damaged mitochondria in AD. We have established mouse and C. elegans AD models to investigate whether mitophagy modifies AD features. Mitophagy will be evaluated using multiple techniques such as immunoblotting for protein expression, a mitophagy reporter worm strain, mitophagy dyes, and an in vivo reporter. We are currently screening known and novel molecules for their ability to alter mitophagy. We will employ these candidate drugs to modulate mitophagy and determine if these treatments offset AD mitochondrial phenotypes.
| Fivenson, Elayne M; Lautrup, Sofie; Sun, Nuo et al. (2017) Mitophagy in neurodegeneration and aging. Neurochem Int 109:202-209 |
| Kerr, Jesse S; Adriaanse, Bryan A; Greig, Nigel H et al. (2017) Mitophagy and Alzheimer's Disease: Cellular and Molecular Mechanisms. Trends Neurosci 40:151-166 |
| Hou, Yujun; Song, Hyundong; Croteau, Deborah L et al. (2017) Genome instability in Alzheimer disease. Mech Ageing Dev 161:83-94 |
