Abstract

Influenza A viruses (IAV) are significant human pathogens causing yearly epidemics and occasional pandemics. Past pandemics have resulted in significant morbidity and mortality. The 1918 influenza pandemic was thought to have resulted in the death of at least 675,000 people in the U.S., and 40 million people worldwide. Pandemics in 1957 and 1968, while less severe, were also of major public health importance. A novel influenza A virus of swine origin became pandemic in 2009, causing the first pandemic in 41 years.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAAI001114-01
Application #
7964780
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2009
Total Cost
$38,914
Indirect Cost

  Institution

Name
National Institute of Allergy and Infectious Diseases
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Safronetz, David; Rockx, Barry; Feldmann, Friederike et al. (2011) Pandemic swine-origin H1N1 influenza A virus isolates show heterogeneous virulence in macaques. J Virol 85:1214-23
Easterbrook, Judith D; Dunfee, Rebecca L; Schwartzman, Louis M et al. (2011) Obese mice have increased morbidity and mortality compared to non-obese mice during infection with the 2009 pandemic H1N1 influenza virus. Influenza Other Respir Viruses 5:418-25
Easterbrook, Judith D; Kash, John C; Sheng, Zong-Mei et al. (2011) Immunization with 1976 swine H1N1- or 2009 pandemic H1N1-inactivated vaccines protects mice from a lethal 1918 influenza infection. Influenza Other Respir Viruses 5:198-205
Jagger, Brett W; Memoli, Matthew J; Sheng, Zong-Mei et al. (2010) The PB2-E627K mutation attenuates viruses containing the 2009 H1N1 influenza pandemic polymerase. MBio 1:
Kash, John C; Qi, Li; Dugan, Vivien G et al. (2010) Prior infection with classical swine H1N1 influenza viruses is associated with protective immunity to the 2009 pandemic H1N1 virus. Influenza Other Respir Viruses 4:121-7
Morens, David M; Taubenberger, Jeffery K; Fauci, Anthony S (2009) The persistent legacy of the 1918 influenza virus. N Engl J Med 361:225-9
Morens, David M; Taubenberger, Jeffery K (2009) Understanding influenza backward. JAMA 302:679-80