Abstract

The study aims at identifying protective immune responses that reduce malaria disease and parasite burden in young children. This study is based on our earlier studies of pregnancy malaria. Susceptibility to pregnancy malaria (PM) results from the unique binding phenotype of placental parasites that adhere to chondroitin sulfate A (CSA). Over successive pregnancies, women develop specific humoral immunity to placental parasites in the form of anti-adhesion antibodies. Anti-adhesion antibodies are associated with improved pregnancy outcomes. To better understand malaria pathogenesis in pregnant women children, and the development of immunity in young children, we established a longitudinal birth cohort in Mali in which women are enrolled during their pregnancy and their newborn children are actively followed up from birth up to 5 years. Blood samples collected from pregnant women and children at fixed time points and at the time of infection are used to: 1. Relate soluble mediators with pregnancy outcomes; 2. Describe parasite binding phenotype; 3. Characterize parasite membrane proteome; 4. Develop anti-adhesion antibodies.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAAI001153-08
Application #
9786469
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
8
Fiscal Year
2018
Total Cost
Indirect Cost

  Institution

Name
Niaid Extramural Activities
Department
Type
DUNS #
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  Publications

Barry, Amadou; Issiaka, Djibrilla; Traore, Tiangoua et al. (2018) Optimal mode for delivery of seasonal malaria chemoprevention in Ouelessebougou, Mali: A cluster randomized trial. PLoS One 13:e0193296
Brickley, E B; Kabyemela, E; Kurtis, J D et al. (2017) Developing a novel risk prediction model for severe malarial anemia. Glob Health Epidemiol Genom 2:e14
Mahamar, Almahamoudou; Issiaka, Djibrilla; Barry, Amadou et al. (2017) Effect of seasonal malaria chemoprevention on the acquisition of antibodies to Plasmodium falciparum antigens in Ouelessebougou, Mali. Malar J 16:289
Mahamar, Almahamoudou; Attaher, Oumar; Swihart, Bruce et al. (2017) Host factors that modify Plasmodium falciparum adhesion to endothelial receptors. Sci Rep 7:13872
Brickley, Elizabeth B; Spottiswoode, Natasha; Kabyemela, Edward et al. (2016) Cord Blood Hepcidin: Cross-Sectional Correlates and Associations with Anemia, Malaria, and Mortality in a Tanzanian Birth Cohort Study. Am J Trop Med Hyg 95:817-826
Gonçalves, Bronner P; Prevots, D Rebecca; Kabyemela, Edward et al. (2016) Preparing for future efficacy trials of severe malaria vaccines. Vaccine 34:1865-7
Brickley, Elizabeth B; Wood, Angela M; Kabyemela, Edward et al. (2015) Fetal origins of malarial disease: cord blood cytokines as risk markers for pediatric severe malarial anemia. J Infect Dis 211:436-44
Raj, Dipak K; Nixon, Christian P; Nixon, Christina E et al. (2014) Antibodies to PfSEA-1 block parasite egress from RBCs and protect against malaria infection. Science 344:871-7
Gonçalves, Bronner P; Fried, Michal; Duffy, Patrick E (2014) Parasite burden and severity of malaria in Tanzanian children. N Engl J Med 371:482
Kabyemela, Edward; Gonçalves, Bronner P; Prevots, D Rebecca et al. (2013) Cytokine profiles at birth predict malaria severity during infancy. PLoS One 8:e77214

Showing the most recent 10 out of 13 publications