The long-term goal of this project is the development of a multivalent anti-S. aureus vaccine/cocktail of anti-S. aureus mAbs that will be composed of several toxoid antigens or mAbs against the most important S. aureus toxins, respectively. In addition, mAbs against PSMα3 will be an indispensable tool for our planned high-throughput screen for agents inhibiting PSM secretion. Specifically, we plan to: Test all PSMα3 derivatives for their immunogenic potential Test all PSMα3 derivatives (active vaccination) in animal protection assays (using skin, bacteremia, and pneumonia infection models) Produce mAbs against PSMα3 and a selection of PSMα3 derivatives Test the efficacy of those mAbs in protecting from S. aureus-induced disease in various infection models (skin, bacteremia, pneumonia) This project has just started. In the current FY, we have initiated production of polyclonal Abs and mAbs against PSMα3.

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Chatterjee, Som S; Otto, Michael (2013) How can Staphylococcus aureus phenol-soluble modulins be targeted to inhibit infection? Future Microbiol 8:693-6
Otto, Michael (2013) Blocking the spread of resistance. Sci Transl Med 5:184fs17
Cheung, Gordon Y C; Otto, Michael (2012) The potential use of toxin antibodies as a strategy for controlling acute Staphylococcus aureus infections. Expert Opin Ther Targets 16:601-12