Abstract

Pregnancy malaria (PM) is a major public health problem associated with severe maternal anemia, preeclampsia, pregnancy loss, low birthweight delivery and infant mortality. PM is caused by sequestration in the placenta of parasites that bind the receptor chondroitin sulfate A (CSA). Previous ex vivo experiments have shown that parasite binding to CSA can be inhibited by antibodies from multigravida women who acquired specific immunity to CSA-binding parasites, or by antibodies from animals immunized with antigens that mediate parasite binding to CSA.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAAI001176-06
Application #
9566748
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
2017
Total Cost
Indirect Cost

  Institution

Name
Niaid Extramural Activities
Department
Type
DUNS #
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State
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  Publications

Doritchamou, Justin Y A; Akuffo, Richard A; Moussiliou, Azizath et al. (2018) Submicroscopic placental infection by non-falciparum Plasmodium spp. PLoS Negl Trop Dis 12:e0006279
Fried, Michal; Kurtis, Jonathan D; Swihart, Bruce et al. (2018) Antibody levels to recombinant VAR2CSA domains vary with Plasmodium falciparum parasitaemia, gestational age, and gravidity, but do not predict pregnancy outcomes. Malar J 17:106
Fried, Michal; Duffy, Patrick E (2017) Malaria during Pregnancy. Cold Spring Harb Perspect Med 7:
Doritchamou, Justin; Teo, Andrew; Fried, Michal et al. (2017) Malaria in pregnancy: the relevance of animal models for vaccine development. Lab Anim (NY) 46:388-398
Doritchamou, Justin Yai Alamou; Herrera, Raul; Aebig, Joan A et al. (2016) VAR2CSA Domain-Specific Analysis of Naturally Acquired Functional Antibodies to Plasmodium falciparum Placental Malaria. J Infect Dis 214:577-86
Fried, Michal; Duffy, Patrick E (2015) Designing a VAR2CSA-based vaccine to prevent placental malaria. Vaccine 33:7483-8
Saveria, Tracy; Oleinikov, Andrew V; Wiliamson, Kathryn et al. (2013) Antibodies to Escherichia coli-expressed C-terminal domains of Plasmodium falciparum variant surface antigen 2-chondroitin sulfate A (VAR2CSA) inhibit binding of CSA-adherent parasites to placental tissue. Infect Immun 81:1031-9
Obiakor, Harold; Avril, Marion; Macdonald, Nicholas J et al. (2013) Identification of VAR2CSA domain-specific inhibitory antibodies of the Plasmodium falciparum erythrocyte membrane protein 1 using a novel flow cytometry assay. Clin Vaccine Immunol 20:433-42