The major discovery this year are as follows. 1. Performed a NHP vaccine and challenge study using Pk CSP Protein and Poly ICLC as an adjuvant with or without rAd5-CSP as a boost. Developed a mosquito challenge model for PK in NHP> 2. Showed that radiation attenuated sporozoites administered intravenously into NHP induced potent CD4 and CD8+ T cell responses in blood and liver. We also developed an assay to measure SPZ specific T cell responses. 3. Demonstrated that a novel full length P. falciparum CSP protein elicited potent CD4+ T cell and humoral immunity in mice sufficient to limit parasite replication in vivo following challenge.

Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
2011
Total Cost
$685,038
Indirect Cost
City
State
Country
Zip Code
Jongo, Said A; Shekalaghe, Seif A; Church, L W Preston et al. (2018) Safety, Immunogenicity, and Protective Efficacy against Controlled Human Malaria Infection of Plasmodium falciparum Sporozoite Vaccine in Tanzanian Adults. Am J Trop Med Hyg 99:338-349
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