This is a preclinical study designed to determine different molecular and gene alterations resulting from various doses and schedules of radiation. The initial study was to determine gene expression profiles of glioma cell lines exposed to low-dose versus high-dose radiation. Six different glioma cell lines were used. After undergoing radiation, RNA was extracted for microarray analysis. Data has been analyzed and further testing has been proposed. The study is now including cell lines from human DIPG and pediatric high grade glioma. An animal model is under development.The study is currently ongoing.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIABC011018-05
Application #
8552937
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
2012
Total Cost
$59,349
Indirect Cost
Name
National Cancer Institute Division of Basic Sciences
Department
Type
DUNS #
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State
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