Stem cell therapy have great potentials in clinical application. ES cells represent an unlimited source to generate all different types of adult stem cells. However, the events during the differentiation of ES cells into adult stem cells are unclear, although it is thought that epigenetic events are critical for this process. We plan to study the chromatin binding proteins in ES cells. Chromatin binding proteins are proteins which are critical for regulating the epigenetic events. Therefore, this project will provide molecular insights into the differentiation process of ES cells and faciliate the clinical utilization of ES cells.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
Application #
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
National Cancer Institute Division of Basic Sciences
Zip Code
Liu, Feng; Barsyte-Lovejoy, Dalia; Allali-Hassani, Abdellah et al. (2011) Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines. J Med Chem 54:6139-50
Li, Mangmang; Huang, Jing (2010) A new puzzling role of p53 in mouse embryonic stem cells. Cell Cycle 9:1669-70
Lee, Kyoung-Hwa; Li, Mangmang; Michalowski, Aleksandra M et al. (2010) A genomewide study identifies the Wnt signaling pathway as a major target of p53 in murine embryonic stem cells. Proc Natl Acad Sci U S A 107:69-74
Yang, Jinbo; Huang, Jing; Dasgupta, Maupali et al. (2010) Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes. Proc Natl Acad Sci U S A 107:21499-504
Huang, Jing; Dorsey, Jean; Chuikov, Sergei et al. (2010) G9a and Glp methylate lysine 373 in the tumor suppressor p53. J Biol Chem 285:9636-41
Zhang, Xinyue; Huang, Jing (2010) Integrative genome-wide approaches in embryonic stem cell research. Integr Biol (Camb) 2:510-6