No progress has been made in improving the outcome of children with diffuse intrinsic pontine glioma in more than 30 years. For other types of pediatric malignant glioma, modest improvements in outcome have been observed; these are primarily due to neurosurgical techniques. Chemotherapeutic agents have not demonstrated significant activity in dipg and have only modest activity in supratentorial malignant gliomas. Children with low grade gliomas have high survival rates, but are faced with a number of lifelong medical, neurocognitive and psychologic issues as a result of therapy. We are studying the biology of pediatric gliomas in an effort to better identify molecular targets, improve our understanding of the pathophysiology of this disease, and improve outcome (survival and quality of life) for children.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIABC011514-06
Application #
9779944
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Basic Sciences
Department
Type
DUNS #
City
State
Country
Zip Code
Morales La Madrid, Andres; Ranjan, Surabhi; Warren, Katherine E (2018) Gliomatosis cerebri: a consensus summary report from the Second International Gliomatosis cerebri Group Meeting, June 22-23, 2017, Bethesda, USA. J Neurooncol 140:1-4
Miyahara, Hiroaki; Yadavilli, Sridevi; Natsumeda, Manabu et al. (2017) The dual mTOR kinase inhibitor TAK228 inhibits tumorigenicity and enhances radiosensitization in diffuse intrinsic pontine glioma. Cancer Lett 400:110-116
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Grasso, Catherine S; Tang, Yujie; Truffaux, Nathalene et al. (2015) Functionally defined therapeutic targets in diffuse intrinsic pontine glioma. Nat Med 21:827
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