1. Investigate expression of PRKD1 in panel of bladder cancer cell lines for expression by western blotting and PCR 2. Investigate expression of PRKD1 in a tissue microarray of bladder cancer tumor specimens 3. Specifically see if knockdown of this protein can induce more aggressive behavior (greater proliferation and/or invasion and migration). 4. Conversely, investigate whether overexpression in cell lines that lack this gene can arrest growth and/or invasion and migration 5. In vivo experiments to follow pending these results

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIABC011592-01
Application #
8938211
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Basic Sciences
Department
Type
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City
State
Country
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