It is known that intestinal epithelial cells (IECs) interact with immune cells to modulate intestinal or systemic immune responses. Dendritic cells (DCs) are one crucial component in maintaining intestinal immune tolerance. However, how IECs and DCs collaborate to maintain the gut immune balance is still unclear. We further found that one transcription factor Foxo1, plays a critical role for IECs function. The loss of Foxo1 within IECs leads to altered mucus layer formation and DCs function. Consequently, mice without Foxo1 in IECs exhibit enhanced susceptibility to intestinal inflammation. We have hypothesized that IEC-derived Foxo1 regulates the IEC-DC interaction for intestinal tolerance via mucin protein. We are currently studying the cellular and molecular mechanisms of how Foxo1 regulates IECs interaction with DCs.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIABC011755-02
Application #
9780045
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Basic Sciences
Department
Type
DUNS #
City
State
Country
Zip Code