Project 1: G alpha s and protein kinase A (PKA) signaling as tumor suppressors. We are investigating the role of cAMP signaling downstream of G alpha s in the development and progression of different cancers, including non-melanoma skin cancer and prostate cancer. By altering the activation of this pathway in human cancer cells and animal models we are dissecting the mechanisms by which this pathway acts as a tumor suppressor. Project 2: G alpha s and PKA as targets for basal cell carcinoma (BCC) treatment. We have demonstrated that inactivation of G alpha s and PKA leads to BCC formation. We are now testing the hypothesis that increasing cAMP and PKA signaling might be a target for reducing BCC proliferation. By using animal models and a human cell line of BCC, we are investigating if the pharmacological activation of this pathway can be used as a target for BCC treatment.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIABC011764-02
Application #
9780053
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Basic Sciences
Department
Type
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State
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