Understanding of factors associated with recovery following allogeneic transplant can increase the likelihood that patients will ultimately return to a normal, productive life. Existing research regarding the recovery of adult survivors of allogeneic HSCT indicates that many patients experience difficulties in a variety of Health Related Quality of Life (HRQL) domains. A critical issue which has remained unexamined concerns the extent to which domains improve, remain static, or perhaps even deteriorates with the passage of time after allogeneic HSCT. This prospective longitudinal study accrued research participants once they have survived a minimum of three years from date of transplant. The protocol provides a mechanism to examine the health status and health outcomes of long term survivors ( 3 years following allogeneic HSCT). Patients were approached for participation during their annual transplant follow-up at the Clinical Center. Patients were evaluated at approximately yearly intervals beyond the first time point within 60 days of their annual transplant follow-up. This parallel with their medical care will allow for potential work in the future comparing biological and self-reported markers of recovery. Questionnaires address topics such as HRQL, functional status, psychosocial adjustment, symptom distress, fatigue, spirituality and sleep quality. The study has closed to enrollment and is currently undergoing data anlaysis. 227 HSCT survivors were screened and 173 enrolled.Results will be discussed with respect to their implications for both the encouragement of realistic expectations for recovery following allogeneic HSCT as well as the development of intervention.

Agency
National Institute of Health (NIH)
Institute
Clinical Center (CLC)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIACL001144-14
Application #
9792169
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
14
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Clinical Center
Department
Type
DUNS #
City
State
Country
Zip Code
Park, Jumin; Wehrlen, Leslie; Mitchell, Sandra A et al. (2018) Fatigue predicts impaired social adjustment in survivors of allogeneic hematopoietic cell transplantation (HCT). Support Care Cancer :
Prince, Patricia; Mitchell, Sandra A; Wehrlen, Leslie et al. (2015) Spiritual Well-Being in Hispanic and Non-Hispanic Survivors of Allogeneic Hematopoietic Stem Cell Transplantation. J Psychosoc Oncol 33:635-54
Bevans, Margaret F; Mitchell, Sandra A; Barrett, John A et al. (2014) Symptom distress predicts long-term health and well-being in allogeneic stem cell transplantation survivors. Biol Blood Marrow Transplant 20:387-95
Ross, Alyson; Friedmann, Erika; Bevans, Margaret et al. (2013) National survey of yoga practitioners: mental and physical health benefits. Complement Ther Med 21:313-23
Kim, Sang Hwan; Schneider, Suzanne M; Bevans, Margaret et al. (2013) PTSD symptom reduction with mindfulness-based stretching and deep breathing exercise: randomized controlled clinical trial of efficacy. J Clin Endocrinol Metab 98:2984-92
Ross, Alyson; Sundaramurthi, Thiruppavai; Bevans, Margaret (2013) A labor of love: the influence of cancer caregiving on health behaviors. Cancer Nurs 36:474-83
Bevans, Margaret; Wehrlen, Leslie; Castro, Kathleen et al. (2013) A problem-solving education intervention in caregivers and patients during allogeneic hematopoietic stem cell transplantation. J Health Psychol :
Ross, Alyson; Friedmann, Erika; Bevans, Margaret et al. (2012) Frequency of yoga practice predicts health: results of a national survey of yoga practitioners. Evid Based Complement Alternat Med 2012:983258
Bevans, Margaret; Sternberg, Esther M (2012) Caregiving burden, stress, and health effects among family caregivers of adult cancer patients. JAMA 307:398-403
Bevans, Margaret F (2011) Complacency is not an option. Blood 118:4506-7

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