Role of Mass Spectrometry in Improving the Diagnosis of Endocrine Disorders

Soldin, Steven

Abstract

We will continue to evaluate the role of steroid profile and thyroid hormone profile monitoring in optimizing both diagnosis and treatment of different endocrine diseases.We will also examine the role of our new free steroid profile and free 25 OH Vitamin D3 assays in health and disease. The work described above has been published in numerous papers, a few of which are listed below. Soldin SJ, Soldin OP. Steroid Hormone Analysis by Tandem Mass Spectrometry. Clin Chem. 2009;55:1061-6. Soldin SJ, Cheng LL, Lam LY, Werner A, Le AD, Soldin OP.Comparison of FT4 with log TSH on the Abbott Architect ci8200: Pediatric reference intervals for free thyroxine and thyroid-stimulating hormone.Clin Chim Acta. 2010;411: 250-2. Jonklaas J, Kahric-Janicic N, Soldin OP, Soldin SJ. Correlations of Free Thyroid Hormones Measured by Tandem Mass Spectrometry and Immunoassay with Thyroid-Stimulating Hormone Across 4 Patient Populations. Clin Chem. 2009;55:1380-88. Soldin OP, Soldin SJ. Thyroid hormone testing by tandem mass spectrometry. Clin Biochem. 2011;44:89-94 Van Deventer HE, Mendu DR, Remaley AT, Soldin SJ. Inverse Log-Linear Relationship between Thyroid-Stimulating Hormone and Free Thyroxine Measured by Direct Analogue Immunoassay and Tandem Mass Spectrometry. Clin Chem 2011 Jan;57(1):122-7. Jonklaas J, Holst JP, Verbalis JG, Pehlivanova M, Soldin SJ. Changes in steroid concentrations with the timing of corticotropin stimulation testing in participants with adrenal insufficiency.Endocr Pract. 2012 Jan-Feb;18(1):66-75. Gounden V, El-Maouche D, Stolze BR, Muniyappa R, Soldin SJ.LC-MS/MS detection of increased Androstenedione levels in patients receiving Danazol therapy.Ther Drug Monit. 2014 May 9. Van Deventer HE, Soldin SJ. The expanding role of tandem mass spectrometry in optimizing diagnosis and treatment of thyroid disease.. Advances in Clinical Chemistry 2013:61;127-152. Gounden V,Jonklaas J, Soldin SJ. A Pilot Study: Subclinical Hypothyroidism and Free Thyroid Hormone Measurement by Immunoassay and Mass Spectrometry. Clinica Chimica Acta 430 (2014) 121124. Stolze BR,Gounden V,Gu J,Merke DP,Skarulis MC,Soldin SJ. An improved micro method for the measurement of steroid profiles by tandem HPLC MSMS andits use in assessing diurnal effects on steroids studied.Submitted to Clin Chem. Gounden V, Soldin SJ. Tacrolimus Measurement: Building a Better Immunoassay. Clin Chem. 2014 Apr;60(4):575-6. Gounden V,Soldin SJ. Clinical Use of Reference Intervals Derived from Some CALIPER Studies Questioned. Clinical Chemistry 2014:60;416-7. Jonklaas J, Sathasivam A, Wang H, Finigan D, Soldin OP, Burman KD, Soldin SJ.3,3'-diiodothyronine concentrations in hospitalized or thyroidectomized patients: results from a pilot study.Endocr Pract. 2014 Aug 1;20(8):797-807 Jonklaas J, Sathasivam A, Wang H, Gu J, Burman KD, Soldin SJ.Total and free thyroxine and triiodothyronine: Measurement discrepancies, particularly in inpatients.Clin Biochem. 2014 Sep;47(13-14):1272-8. Debono M, Mallappa A, Gounden V, Nella AA, Harrison RF, Crutchfield CA, Backlund PS, Soldin SJ, Ross RJ, Merke DP.Hormonal Circadian Rhythms in Patients with Congenital Adrenal Hyperplasia: Identifying Optimal Monitoring Times and Novel Disease Biomarkers.Eur J Endocrinol. 2015 Sep 4. pii: EJE-15-0064

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: Clinical Center (CLC)
• Type: Investigator-Initiated Intramural Research Projects (ZIA)
• Project #: 1ZIACL010355-03
• Application #: 9154091
• Support Year: 3
• Fiscal Year: 2015

Institution

• Name: Clinical Center

Publications

Ling, C; Sun, Q; Khang, J et al. (2018) Does TSH Reliably Detect Hypothyroid Patients? Ann Thyroid Res 4:122-125

Mallappa, Ashwini; Nella, Aikaterini A; Sinaii, Ninet et al. (2018) Long-term use of continuous subcutaneous hydrocortisone infusion therapy in patients with congenital adrenal hyperplasia. Clin Endocrinol (Oxf) 89:399-407

Sun, Qian; Gu, Jianghong; Stolze, Brian R et al. (2018) Atmospheric Pressure Chemical Ionization Is a Suboptimal Ionization Source for Steroids. Clin Chem 64:974-976

Welsh, Kerry J; Stolze, Brian R; Yu, Xiaolin et al. (2017) Assessment of thyroid function in intensive care unit patients by liquid chromatography tandem mass spectrometry methods. Clin Biochem 50:318-322

Nilubol, Naris; Soldin, Steven J; Patel, Dhaval et al. (2017) 11-Deoxycortisol may be superior to cortisol in confirming a successful adrenal vein catheterization without cosyntropin: a pilot study. Int J Endocr Oncol 4:75-83

Hannah-Shmouni, Fady; Soldin, Steven J (2017) Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism. N Engl J Med 377:e20

Stolze, Brian R; Gounden, Verena; Gu, Jianghong et al. (2016) An improved micro-method for the measurement of steroid profiles by APPI-LC-MS/MS and its use in assessing diurnal effects on steroid concentrations and optimizing the diagnosis and treatment of adrenal insufficiency and CAH. J Steroid Biochem Mol Biol 162:110-6

Nella, Aikaterini A; Mallappa, Ashwini; Perritt, Ashley F et al. (2016) A Phase 2 Study of Continuous Subcutaneous Hydrocortisone Infusion in Adults with Congenital Adrenal Hyperplasia. J Clin Endocrinol Metab :jc20161916

Welsh, Kerry J; Soldin, Steven J (2016) DIAGNOSIS OF ENDOCRINE DISEASE: How reliable are free thyroid and total T3 hormone assays? Eur J Endocrinol 175:R255-R263

Masika, Likhona Siphe; Zhao, Zhen; Soldin, Steven John (2016) Is measurement of TT3 by immunoassay reliable at low concentrations? A comparison of the Roche Cobas 6000 vs. LC-MSMS. Clin Biochem 49:846-9