Persistent and chronic infections are maintained by a dynamic modulation of microbe - host cell interactions. During this process, microorganisms evolve and adapt to the host by regulating the expression of different genes, in particular those involved in virulence. At the bacterial population level, specific (possibly hypervirulent) clones may predominate at different times in individuals as well as groups of patients. The timely storage of microbial pathogens in the microbiology laboratory together with the availability of clinical data from the patients allows following virulence traits, host adaptation and changing epidemiology of the pathogens. Two specific examples are summarized below: 1) Work on Mycobacterium abscessus revealed high relatedness between strains involved in global outbreaks in cystic fibrosis patients. Serial isolates from the index case of a CF outbreak iprovided valuable insights on the adaptative changes of M. abscessus towards more virulent and possibly more transmissible populations. Interestingly, M. abscessus adaptation and virulence traits share some striking similarities to Mycobacterium tuberculosis. 2) We have recently described a novel and emerging species of molds causing disease in immunocompromised patients. One example is the recovery of a recently described species of Mucor spp from several immunocompromised patients. Whole genome sequencing and comparative genomics of invasive and non invasive Mucor strains is underway.

National Institute of Health (NIH)
Clinical Center (CLC)
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
Application #
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Clinical Center
Zip Code
Esteve-Sole, Ana; Sánchez-Dávila, Suly P; Deyà-Martínez, Angela et al. (2018) Severe BCG-osis Misdiagnosed as Multidrug-Resistant Tuberculosis in an IL-12R?1-Deficient Peruvian Girl. J Clin Immunol 38:712-716
da Silva, Joas L; Nguyen, Jan; Fennelly, Kevin P et al. (2018) Survival of pathogenic Mycobacterium abscessus subsp. massiliense in Acanthamoeba castellanii. Res Microbiol 169:56-60
Matsuyama, Masashi; Martins, Andrew J; Shallom, Shamira et al. (2018) Transcriptional Response of Respiratory Epithelium to Nontuberculous Mycobacteria. Am J Respir Cell Mol Biol 58:241-252
Adjemian, Jennifer; Frankland, Timothy B; Daida, Yihe G et al. (2017) Epidemiology of Nontuberculous Mycobacterial Lung Disease and Tuberculosis, Hawaii, USA. Emerg Infect Dis 23:439-447
Spaulding, Alicen B; Lai, Yi Ling; Zelazny, Adrian M et al. (2017) Geographic Distribution of Nontuberculous Mycobacterial Species Identified among Clinical Isolates in the United States, 2009-2013. Ann Am Thorac Soc :
Kwon-Chung, Kyung J; Bennett, John E; Wickes, Brian L et al. (2017) The Case for Adopting the ""Species Complex"" Nomenclature for the Etiologic Agents of Cryptococcosis. mSphere 2:
Haidar, Ghady; Zerbe, Christa S; Cheng, Michelle et al. (2017) Phellinus species: An emerging cause of refractory fungal infections in patients with X-linked chronic granulomatous disease. Mycoses 60:155-160
Falcone, E Liana; Petts, Jennifer R; Fasano, Mary Beth et al. (2016) Methylotroph Infections and Chronic Granulomatous Disease. Emerg Infect Dis 22:404-9
Fleshner, M; Olivier, K N; Shaw, P A et al. (2016) Mortality among patients with pulmonary non-tuberculous mycobacteria disease. Int J Tuberc Lung Dis 20:582-7
Falcone, E Liana; Abusleme, Loreto; Swamydas, Muthulekha et al. (2016) Colitis susceptibility in p47(phox-/-) mice is mediated by the microbiome. Microbiome 4:13

Showing the most recent 10 out of 47 publications