This project includes two studies: 1) the Shanghai Biliary Tract Cancer Study, 2)the Chile Gallbladder Cancer Study. These studies complement each other and will provide unique insight into the etiology of biliary tract cancer. The Shanghai Study includes more than 3,000 subjects, including over 600 biliary tract cancer patients, 900 gallstone patients, and 1,000 healthy controls randomly selected from the population. A structured questionnaire was used to elicit information on epidemiologic risk factors, including smoking, drinking, diet, medical history, and reproductive factors. The study had a strong biochemical and molecular component with an extensive collection of biological samples, including serum, DNA, gallstones, bile, and tissue samples. The Chile Gallbladder Cancer Study includes a pilot study of 120 subjects. The full-scale study will include 4000 cases of gallbladder cancer and 4000 controls enrolled from 12 locations in Chile, which has the highest risk of gallbladder cancer in the world. Similar to the Shanghai Study, the Chile Study will incorporate extensive biospecimen collection. It will complement the Shanghai Study by allowing replication and validation of previous findings, as well as evaluation of unique exposure (i.e. salmonella typhi and heavy metals).

National Institute of Health (NIH)
National Cancer Institute (NCI)
Investigator-Initiated Intramural Research Projects (ZIA)
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Cancer Epidemiology and Genetics
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Liu, Zhiwei; Kemp, Troy J; Gao, Yu-Tang et al. (2018) Circulating Levels of Inflammatory Proteins and Survival in Patients with Gallbladder Cancer. Sci Rep 8:5671
Liu, Zhiwei; Kemp, Troy J; Gao, Yu-Tang et al. (2018) Association of circulating inflammation proteins and gallstone disease. J Gastroenterol Hepatol :
Koshiol, Jill; Gao, Yu-Tang; Corbel, Amanda et al. (2018) Circulating inflammatory proteins and gallbladder cancer: Potential for risk stratification to improve prioritization for cholecystectomy in high-risk regions. Cancer Epidemiol 54:25-30
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Koshiol, Jill; Wozniak, Aniela; Cook, Paz et al. (2016) Salmonella enterica serovar Typhi and gallbladder cancer: a case-control study and meta-analysis. Cancer Med 5:3310-3235
Van Dyke, Alison L; Kemp, Troy J; Corbel, Amanda F et al. (2016) Lipopolysaccharide-pathway proteins are associated with gallbladder cancer among adults in Shanghai, China with mediation by systemic inflammation. Ann Epidemiol 26:704-709
Ferreccio, Catterina; Roa, Juan Carlos; Bambs, Claudia et al. (2016) Study protocol for the Maule Cohort (MAUCO) of chronic diseases, Chile 2014-2024. BMC Public Health 16:122
Koshiol, Jill; Castro, Felipe; Kemp, Troy J et al. (2016) Association of inflammatory and other immune markers with gallbladder cancer: Results from two independent case-control studies. Cytokine 83:217-225
Espinoza, Jaime A; Bizama, Carolina; GarcĂ­a, Patricia et al. (2016) The inflammatory inception of gallbladder cancer. Biochim Biophys Acta 1865:245-54

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