Thyroid cancer incidence rates have been increasing for the last 3 decades in the US and the reasons for this are largely unknown. We have been studying potential risk factors for the disease in a pooled analysis of 5 NCI prospective studies. This pooling project provided some of the strongest evidence to date that obesity may be a risk factor for thyroid cancer and the rising obesity rates could therefore be part of the explanation for the rise in thyroid cancer incidence rates. We are now expanding this pooling project to include data from 15 European and US cohorts to examine the relationship in more detail including the risk associated with central adiposity and the relationship between obesity and rarer thyroid cancer subtypes.NCI Cohort Consortium BMI Pooling Project - We built a rich dataset of lifestyle risk factor and mortality data from 20 prospective studies and over 1.5 million people to study the relationship between BMI and all cause mortality. The results from this detailed analysis published in 2010 suggested that optimal BMI was in the range 20-25. We are currently exploring the association between waist circumference and all cause mortality, and expanding the pooling project to look at cancer incidence for rare cancers including thyroid and gallbladder. These cancers are typically difficult to study in individual cohorts because the numbers of cases is limited.Childhood Cancer In Chinese Children and Family Cohorts -We are conducting two pilot studies to test the feasibility of (1) follow and participation in interviews of a sample of 500 families from two county sites where the Community Intervention Program (CIP) was carried out in the mid-1990s and (2) identification of incident pediatric cancers arising among thoseborn during 1994-96 in hospitals serving the CIP population and ability to link these pediatric cancer patients back to the CIP population. The CIP community intervention program trial, which was carried out during 1994-96 in three large counties northeast and south of Beijing, evaluated the effectiveness of periconceptional folic acid supplements in reducing neural tube defects. There were dramaticreductions in neural tube defects among offspring of mothers who took folic acid supplements during thepericonceptional period. Publications from case-control epidemiologic studies in the past 10 years from Western countries have shown that periconceptional folic acid supplements may reduce risks of pediatric leukemia and potentially other pediatric cancers in offspring of mothers who take these supplements. Otherstudies have shown statistical associations with periconception folic acid and other serious chronic diseasesof offspring including asthma. The pilot studies will attempt to trace, enroll, and interview 500 families fromTaicang, Jiangsu Province and Laoting, Hebei Province and will seek to identify all pediatric cancers diagnosedduring 1994 to the present among children born during 1994-96 and link these children back to the CIP cohort.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIACP010219-07
Application #
9549678
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
7
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Cancer Epidemiology and Genetics
Department
Type
DUNS #
City
State
Country
Zip Code
Lim, Hyeyeun; Devesa, Susan S; Sosa, Julie A et al. (2017) Trends in Thyroid Cancer Incidence and Mortality in the United States, 1974-2013. JAMA 317:1338-1348
Kitahara, Cari M (2017) New Evidence on the Association between Prediagnostic Thyroid-Stimulating Hormone Levels and Thyroid Cancer Risk. Cancer Epidemiol Biomarkers Prev 26:1163-1164
Moore, Steven C; Lee, I-Min; Weiderpass, Elisabete et al. (2016) Association of Leisure-Time Physical Activity With Risk of 26 Types of Cancer in 1.44 Million Adults. JAMA Intern Med 176:816-25
Kitahara, Cari M; Sosa, Julie A (2016) The changing incidence of thyroid cancer. Nat Rev Endocrinol :
Genkinger, J M; Kitahara, C M; Bernstein, L et al. (2015) Central adiposity, obesity during early adulthood, and pancreatic cancer mortality in a pooled analysis of cohort studies. Ann Oncol 26:2257-66
Braganza, Melissa Z; Potischman, Nancy; Park, Yikyung et al. (2015) Adolescent and mid-life diet and subsequent risk of thyroid cancer in the NIH-AARP diet and health study. Int J Cancer 137:2413-23
Gaudet, Mia M; Kitahara, Cari M; Newton, Christina C et al. (2015) Anthropometry and head and neck cancer:a pooled analysis of cohort data. Int J Epidemiol 44:673-81
Kitahara, Cari M; Gamborg, Michael; Berrington de González, Amy et al. (2014) Childhood height and body mass index were associated with risk of adult thyroid cancer in a large cohort study. Cancer Res 74:235-42
Park, Yikyung; Wang, Sophia; Kitahara, Cari M et al. (2014) Body mass index and risk of death in Asian Americans. Am J Public Health 104:520-5
Teras, Lauren R; Kitahara, Cari M; Birmann, Brenda M et al. (2014) Body size and multiple myeloma mortality: a pooled analysis of 20 prospective studies. Br J Haematol 166:667-76

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