Abstract

The stress system is well known to play an important role in relapse to drug abuse and excessive eating and is largely controlled by corticotropin releasing hormone receptors (CRHR) and their endogenous ligands. Earlier we showed that intermittent access to highly palatable food induced anxiety-like behavior that was reversible by CRHR1 antagonists such as antalarmin indicating that such antagonists may be useful in the treatment of human eating disorders. Nonpeptide antagonists of corticotropin hormone receptor system have also been shown to blunt excessive eating in animal models of binge eating with high sucrose low fat diets. During the reporting period, we studied the brain regions that mediate these behaviors by using a combination of CRH immunostaining and microinjection of of the CRHR1 antagonist R121919 into the central nucleus of the amygdala (CeA), the bed nucleus of the stria terminalis (BNST) and the basolateral nucleus of the amygdala (BIA). Our results showed that the CEA and BIA have differential roles in the mediating maladaptive behaviors associated with palatable food-associated stress.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIADA000528-06
Application #
8736752
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
2013
Total Cost
$109,499
Indirect Cost

  Institution

Name
National Institute on Drug Abuse
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Dong, Hongxin; Keegan, Jack M; Hong, Ellie et al. (2018) Corticotrophin releasing factor receptor 1 antagonists prevent chronic stress-induced behavioral changes and synapse loss in aged rats. Psychoneuroendocrinology 90:92-101
Micioni Di Bonaventura, Maria Vittoria; Ubaldi, Massimo; Giusepponi, Maria Elena et al. (2017) Hypothalamic CRF1 receptor mechanisms are not sufficient to account for binge-like palatable food consumption in female rats. Int J Eat Disord 50:1194-1204
Zhang, Cheng; Kuo, Ching-Chang; Moghadam, Setareh H et al. (2016) Corticotropin-releasing factor receptor-1 antagonism mitigates beta amyloid pathology and cognitive and synaptic deficits in a mouse model of Alzheimer's disease. Alzheimers Dement 12:527-37
Pomrenze, Matthew B; Millan, E Zayra; Hopf, F Woodward et al. (2015) A Transgenic Rat for Investigating the Anatomy and Function of Corticotrophin Releasing Factor Circuits. Front Neurosci 9:487
Zhang, Cheng; Kuo, Ching-Chang; Moghadam, Setareh H et al. (2015) Corticotropin-Releasing Factor Receptor-1 Antagonism Reduces Oxidative Damage in an Alzheimer’s Disease Transgenic Mouse Model. J Alzheimers Dis 45:639-50
Northcutt, A L; Hutchinson, M R; Wang, X et al. (2015) DAT isn't all that: cocaine reward and reinforcement require Toll-like receptor 4 signaling. Mol Psychiatry 20:1525-37
Campbell, Shannon N; Zhang, Cheng; Monte, Louise et al. (2015) Increased tau phosphorylation and aggregation in the hippocampus of mice overexpressing corticotropin-releasing factor. J Alzheimers Dis 43:967-76
Dong, Hongxin; Wang, Shirlene; Zeng, Ziling et al. (2014) Effects of corticotrophin-releasing factor receptor 1 antagonists on amyloid-? and behavior in Tg2576 mice. Psychopharmacology (Berl) 231:4711-22
Micioni Di Bonaventura, Maria Vittoria; Ciccocioppo, Roberto; Romano, Adele et al. (2014) Role of bed nucleus of the stria terminalis corticotrophin-releasing factor receptors in frustration stress-induced binge-like palatable food consumption in female rats with a history of food restriction. J Neurosci 34:11316-24
Iemolo, Attilio; Blasio, Angelo; St Cyr, Stephen A et al. (2013) CRF-CRF1 receptor system in the central and basolateral nuclei of the amygdala differentially mediates excessive eating of palatable food. Neuropsychopharmacology 38:2456-66

Showing the most recent 10 out of 18 publications