Abstract

The abuse of MDMA and other hallucinogenic drugs continues to be a serious problem that is exacerbated by the recent publication of cookbook chemical syntheses and detailed accounts of the doses used and hallucinogenic effects seen in humans for almost all of the 179 phenethylamine and 53 tryptamine analogs that were synthesized and self-administered by A. T. Shulgin and his associates during more than 30 years. These are disturbing developments that substantially aid and encourage clandestine drug production and may presage a resurgence in hallucinogenic drug abuse. We have begun a program to synthesize and evaluate a number of hallucinogenic agents and their antagonists. We recently developed a practical nonchromatographic chemical synthesis of the 5-HT2A receptor antagonist MDL100,907 that is providing this important research tool. We have studied the discriminative stimulus effects of several of these drugs in order to gain further insight into their 5-HT receptor subtype(s) selectivity and the possible receptor role in certain neuropsychiatric disorders. Our results provide quantitative evidence for the predominant, if not exclusive, role of 5-HT(2A) receptors in the discriminative stimulus effects of DOM, 2C-T-7, and DPT in rhesus monkeys.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIADA000529-02
Application #
7966904
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
2009
Total Cost
$56,591
Indirect Cost

  Institution

Name
National Institute on Drug Abuse
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Anizan, Sebastien; Concheiro, Marta; Lehner, Kurt R et al. (2016) Linear pharmacokinetics of 3,4-methylenedioxypyrovalerone (MDPV) and its metabolites in the rat: relationship to pharmacodynamic effects. Addict Biol 21:339-47
Gannon, Brenda M; Williamson, Adrian; Suzuki, Masaki et al. (2016) Stereoselective Effects of Abused ""Bath Salt"" Constituent 3,4-Methylenedioxypyrovalerone in Mice: Drug Discrimination, Locomotor Activity, and Thermoregulation. J Pharmacol Exp Ther 356:615-23
Woloshchuk, Claudia J; Nelson, Katharine H; Rice, Kenner C et al. (2016) Effects of 3,4-methylenedioxypyrovalerone (MDPV) pre-exposure on the aversive effects of MDPV, cocaine and lithium chloride: Implications for abuse vulnerability. Drug Alcohol Depend 167:121-7
Collins, Gregory T; Abbott, Megan; Galindo, Kayla et al. (2016) Discriminative Stimulus Effects of Binary Drug Mixtures: Studies with Cocaine, MDPV, and Caffeine. J Pharmacol Exp Ther 359:1-10
King, Heather E; Wetzell, Bradley; Rice, Kenner C et al. (2015) An assessment of MDPV-induced place preference in adult Sprague-Dawley rats. Drug Alcohol Depend 146:116-9
Suzuki, Masaki; Deschamps, Jeffrey R; Jacobson, Arthur E et al. (2015) Chiral resolution and absolute configuration of the enantiomers of the psychoactive ""designer drug"" 3,4-methylenedioxypyrovalerone. Chirality 27:287-93
Blasio, Angelo; Valenza, Marta; Iyer, Malliga R et al. (2015) Sigma-1 receptor mediates acquisition of alcohol drinking and seeking behavior in alcohol-preferring rats. Behav Brain Res 287:315-22
King, Heather E; Wakeford, Alison; Taylor, William et al. (2015) Sex differences in 3,4-methylenedioxypyrovalerone (MDPV)-induced taste avoidance and place preferences. Pharmacol Biochem Behav 137:16-22
Flax, Shaun M; Wakeford, Alison G P; Cheng, Kejun et al. (2015) Effect of norbinaltorphimine on ??-tetrahydrocannabinol (THC)-induced taste avoidance in adolescent and adult Sprague-Dawley rats. Psychopharmacology (Berl) 232:3193-201
Blasio, Angelo; Rice, Kenner C; Sabino, Valentina et al. (2014) Characterization of a shortened model of diet alternation in female rats: effects of the CB1 receptor antagonist rimonabant on food intake and anxiety-like behavior. Behav Pharmacol 25:609-17

Showing the most recent 10 out of 28 publications