Using our custom developed miniScope system, we imaged neuronal activity in dorsal striatum in freely moving mice, we also recorded mice locomotor activity, and compared neuronal activity to mice locomotor activity. We found that direct and indirect pathway neurons in the dorsal striatum displayed similar population activity. We further construct neuron cluster models based on our calcium recordings, and uncovered functional heterogeneity amount direct and indirect pathway neurons in dorsal striatum. Going forward, we will use this imaging technique to study how cocaine, THC and other substances of abuse alters dorsal striatum neuronal circuit function, and their contribution in the development of long-term drug addiction and relapse

Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2015
Total Cost
Indirect Cost
Name
National Institute on Drug Abuse
Department
Type
DUNS #
City
State
Country
Zip Code
Chun, Lani S; Vekariya, Rakesh H; Free, R Benjamin et al. (2018) Structure-Activity Investigation of a G Protein-Biased Agonist Reveals Molecular Determinants for Biased Signaling of the D2 Dopamine Receptor. Front Synaptic Neurosci 10:2
Abulseoud, Osama A; Zuccoli, Maria Laura; Zhang, Lifeng et al. (2017) The acute effect of cannabis on plasma, liver and brain ammonia dynamics, a translational study. Eur Neuropsychopharmacol 27:679-690
Etzler, Julie C; Bollo, Mariana; Holstein, Deborah et al. (2017) Cyclophilin D over-expression increases mitochondrial complex III activity and accelerates supercomplex formation. Arch Biochem Biophys 613:61-68
Zhang, Wen; Daly, Kathryn M; Liang, Bo et al. (2016) BDNF rescues prefrontal dysfunction elicited by pyramidal neuron-specific DTNBP1 deletion in vivo. J Mol Cell Biol :
Zhang, Wen; Zhang, Lifeng; Liang, Bo et al. (2016) Hyperactive somatostatin interneurons contribute to excitotoxicity in neurodegenerative disorders. Nat Neurosci 19:557-559
Barbera, Giovanni; Liang, Bo; Zhang, Lifeng et al. (2016) Spatially Compact Neural Clusters in the Dorsal Striatum Encode Locomotion Relevant Information. Neuron 92:202-213
Gu, Yi; Chiu, Shu-Ling; Liu, Bian et al. (2016) Differential vesicular sorting of AMPA and GABAA receptors. Proc Natl Acad Sci U S A 113:E922-31
Zhang, Yong; Cudmore, Robert H; Lin, Da-Ting et al. (2015) Visualization of NMDA receptor-dependent AMPA receptor synaptic plasticity in vivo. Nat Neurosci 18:402-7
Zhang, Xian; An, Xu; Liu, Hanxiao et al. (2015) The topographical arrangement of cutoff spatial frequencies across lower and upper visual fields in mouse V1. Sci Rep 5:7734
Lee, Steven T; Williams, Pete A; Braine, Catherine E et al. (2015) A Miniature, Fiber-Coupled, Wireless, Deep-Brain Optogenetic Stimulator. IEEE Trans Neural Syst Rehabil Eng 23:655-64

Showing the most recent 10 out of 12 publications