The Secretory Mechanisms and Dysfunction Section investigates the molecular nature and function of the ion transport mechanisms involved in the fluid and electrolyte secretion process in the exocrine salivary gland. We are probing the structure-function relationships of cotransporter, exchanger and channel proteins using a combination of molecular biology, gene modification, proteomics and functional studies in mouse and human salivary glands. We are using a high-throughput approach to catalogue the human saliva proteome, to identify salivary biomarkers for human diseases, and to compile a comprehensive list of the plasma membrane proteins expressed in salivary glands.

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National Institute of Dental & Craniofacial Research
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Gao, Xin; Oei, Maria S; Ovitt, Catherine E et al. (2018) Transcriptional profiling reveals gland-specific differential expression in the three major salivary glands of the adult mouse. Physiol Genomics 50:263-271
Mukaibo, Taro; Munemasa, Takashi; George, Alvin T et al. (2018) The apical anion exchanger Slc26a6 promotes oxalate secretion by murine submandibular gland acinar cells. J Biol Chem 293:6259-6268
Vera-Sigüenza, Elías; Catalán, Marcelo A; Peña-Münzenmayer, Gaspar et al. (2018) A Mathematical Model Supports a Key Role for Ae4 (Slc4a9) in Salivary Gland Secretion. Bull Math Biol 80:255-282
Mukaibo, T; Munemasa, T; Masaki, C et al. (2018) Defective NaCl Reabsorption in Salivary Glands of Eda-Null X-LHED Mice. J Dent Res 97:1244-1251
Alevizos, I; Zheng, C; Cotrim, A P et al. (2017) Late responses to adenoviral-mediated transfer of the aquaporin-1 gene for radiation-induced salivary hypofunction. Gene Ther 24:176-186
Yang, Chengtao; Gonzalez-Perez, Vivian; Mukaibo, Taro et al. (2017) Knockout of the LRRC26 subunit reveals a primary role of LRRC26-containing BK channels in secretory epithelial cells. Proc Natl Acad Sci U S A 114:E3739-E3747
Jalali, Rozita; Lodder, Johannes C; Zandieh-Doulabi, Behrouz et al. (2017) The Role of Na:K:2Cl Cotransporter 1 (NKCC1/SLC12A2) in Dental Epithelium during Enamel Formation in Mice. Front Physiol 8:924
Peña-Münzenmayer, Gaspar; George, Alvin T; Shull, Gary E et al. (2016) Ae4 (Slc4a9) is an electroneutral monovalent cation-dependent Cl-/HCO3- exchanger. J Gen Physiol 147:423-36
Henríquez, C; Riquelme, T T; Vera, D et al. (2016) The calcium-activated potassium channel KCa3.1 plays a central role in the chemotactic response of mammalian neutrophils. Acta Physiol (Oxf) 216:132-45
Wang, Ching-Shuen; Wee, Yinshen; Yang, Chieh-Hsiang et al. (2016) ALX/FPR2 Modulates Anti-Inflammatory Responses in Mouse Submandibular Gland. Sci Rep 6:24244

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