Abstract

Obesity is a continuing problem. Understanding the relationship between systemic inflammation and insulin resistance and its role in the regulation of FFA and glucose by insulin is essential. Background: Quantitative evaluation of insulin regulation on plasma glucose and free fatty acid (FFA) in response to external glucose challenge is clinically important to assess the development of insulin resistance. Mathematical minimal models (MMs) based on insulin modified frequently-sampled intravenous glucose tolerance tests (IM-FSIGT) are widely applied to ascertain an insulin sensitivity index. However, the action of insulin on FFA kinetics is not considered in most MMs. Our contribution in this collaboration with the Yanovski lab is in assessing possible changes in insulin resistance and FFA clearance upon treatment with colchicine.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIADK013030-12
Application #
9773529
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
12
Fiscal Year
2018
Total Cost
Indirect Cost

  Institution

Name
U.S. National Inst Diabetes/Digst/Kidney
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Li, Yanjun; Chow, Carson C; Courville, Amber B et al. (2016) Modeling glucose and free fatty acid kinetics in glucose and meal tolerance test. Theor Biol Med Model 13:8
Thoreson, Caroline K; Chung, Stephanie T; Ricks, Madia et al. (2015) Biochemical and clinical deficiency is uncommon in African immigrants despite a high prevalence of low vitamin D: the Africans in America study. Osteoporos Int 26:2607-2615
Adler-Wailes, Diane C; Periwal, Vipul; Ali, Asem H et al. (2013) Sex-associated differences in free fatty acid flux of obese adolescents. J Clin Endocrinol Metab 98:1676-84
Heuett, William J; Miller 3rd, Bernard V; Racette, Susan B et al. (2012) Bayesian functional integral method for inferring continuous data from discrete measurements. Biophys J 102:399-406
Chow, Carson C; Periwal, Vipul; Csako, Gyorgy et al. (2011) Higher acute insulin response to glucose may determine greater free fatty acid clearance in African-American women. J Clin Endocrinol Metab 96:2456-63
Periwal, Vipul; Chow, Carson C; Bergman, Richard N et al. (2008) Evaluation of quantitative models of the effect of insulin on lipolysis and glucose disposal. Am J Physiol Regul Integr Comp Physiol 295:R1089-96