We are conducting a cross-sectional, case-controlled study of energy expenditure in subjects with narcolepsy, who will be individually matched with healthy controls. The primary objectives of this study is to determine whether hypocretin-deficient subjects with narcolepsy have lower energy expenditure as determined by a 24h stay in the metabolic chamber. During an inpatient visit of approximately 3-4 weeks following screening and medication washout the following additional parameters will be assessed: physical activity (by doubly labeled water study and activity monitors);food intake (dietary history, experimental in-house buffet and food vending machines with computerized access code), body composition (dexa measurements and abdomen CT);measurements of cutaneous and core body temperature and heart rate variability, both indirect indices of autonomic nervous system activity. Endocrine in-depth characterization will include insulin resistance (oral and iv glucose tolerance test), leptin and gh-relin levels as well as characterization of the main neuroendocrine axes.

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Galli, G; Piaggi, P; Mattingly, M S et al. (2013) Inverse relationship of food and alcohol intake to sleep measures in obesity. Nutr Diabetes 3:e58
Lucassen, Eliane A; Rother, Kristina I; Cizza, Giovanni (2012) Interacting epidemics? Sleep curtailment, insulin resistance, and obesity. Ann N Y Acad Sci 1264:110-34
Cizza, G; Requena, M; Galli, G et al. (2011) Chronic sleep deprivation and seasonality: implications for the obesity epidemic. J Endocrinol Invest 34:793-800
Cizza, Giovanni; Nguyen, Vi T; Eskandari, Farideh et al. (2010) Low 24-hour adiponectin and high nocturnal leptin concentrations in a case-control study of community-dwelling premenopausal women with major depressive disorder: the Premenopausal, Osteopenia/Osteoporosis, Women, Alendronate, Depression (POWER) study. J Clin Psychiatry 71:1079-87
Cizza, G; Eskandari, F; Coyle, M et al. (2009) Plasma CRP levels in premenopausal women with major depression: a 12-month controlled study. Horm Metab Res 41:641-8