Abstract

Progress in FY2016 includes the following: Our work summarized in the FY2015 report on chronic BAT stimulation with CL316243, a beta3-adrenergic agonist in mice at thermoneutrality (30C) and at a typical vivarium temperature (22C) has been published (1). We also published a review on Brs3, which activates BAT (2). Our interest in hypothermia is intimately tied to BAT, as induction of hypothermia involves complete inactivation of BAT, which recover reactivates it. Thus studies of drugs causing hypothermia should interact in the neural pathways that contribute to the regulation and control of BAT.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIADK075064-05
Application #
9356209
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
2016
Total Cost
Indirect Cost

  Institution

Name
U.S. National Inst Diabetes/Digst/Kidney
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Reitman, Marc L (2018) Of mice and men - environmental temperature, body temperature, and treatment of obesity. FEBS Lett 592:2098-2107
Reitman, Marc L (2017) How Does Fat Transition from White to Beige? Cell Metab 26:14-16
Xiao, Cuiying; Reitman, Marc L (2016) Bombesin-Like Receptor 3: Physiology of a Functional Orphan. Trends Endocrinol Metab 27:603-605
Xiao, Cuiying; Goldgof, Margalit; Gavrilova, Oksana et al. (2015) Anti-obesity and metabolic efficacy of the ?3-adrenergic agonist, CL316243, in mice at thermoneutrality compared to 22°C. Obesity (Silver Spring) 23:1450-9
Abreu-Vieira, Gustavo; Xiao, Cuiying; Gavrilova, Oksana et al. (2015) Integration of body temperature into the analysis of energy expenditure in the mouse. Mol Metab 4:461-70
Ravussin, Yann; Xiao, Cuiying; Gavrilova, Oksana et al. (2014) Effect of intermittent cold exposure on brown fat activation, obesity, and energy homeostasis in mice. PLoS One 9:e85876
Tschöp, Matthias H; Speakman, John R; Arch, Jonathan R S et al. (2011) A guide to analysis of mouse energy metabolism. Nat Methods 9:57-63