Abstract

Experimental techniques employed are analytical ultracentrifugation, static and dynamic light scattering, field flow fractionation, isothermal titration microcalorimetry, differential scanning calorimetry, circular dichroism spectroscopy, and surface plasmon resonance biosensing. Molecules studied in this project include MHC-like viral proteins, extracellular domains of glutamate receptors, adaptor proteins involved in the formation of signaling particles after T-cell activation, the enzyme ROR-alpha, the adaptor protein TIRAP of the Toll-like receptor and MyD88, the anthrax edema factor interaction with calmodulin and a monoclonal antibody, tubulin, and peptides derived from malarial surface proteins.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAEB000008-03
Application #
7967861
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
2009
Total Cost
$149,349
Indirect Cost

  Institution

Name
National Institute of Biomedical Imaging and Bioengineering
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Lira, André L; Ferreira, Rodrigo S; Torquato, Ricardo J S et al. (2018) Binding kinetics of ultrasmall gold nanoparticles with proteins. Nanoscale 10:3235-3244
Ge, Jingpeng; Elferich, Johannes; Goehring, April et al. (2018) Structure of mouse protocadherin 15 of the stereocilia tip link in complex with LHFPL5. Elife 7:
Zhao, Huaying; Lomash, Suvendu; Chittori, Sagar et al. (2017) Preferential assembly of heteromeric kainate and AMPA receptor amino terminal domains. Elife 6:
Sagar, Vatsala; Chaturvedi, Sumit K; Schuck, Peter et al. (2017) Crystal Structure of Chicken ?S-Crystallin Reveals Lattice Contacts with Implications for Function in the Lens and the Evolution of the ??-Crystallins. Structure 25:1068-1078.e2
Natarajan, Kannan; McShan, Andrew C; Jiang, Jiansheng et al. (2017) An allosteric site in the T-cell receptor C? domain plays a critical signalling role. Nat Commun 8:15260
Sousa, Alioscka A; Hassan, Sergio A; Knittel, Luiza L et al. (2016) Biointeractions of ultrasmall glutathione-coated gold nanoparticles: effect of small size variations. Nanoscale 8:6577-88
Morozov, Giora I; Zhao, Huaying; Mage, Michael G et al. (2016) Interaction of TAPBPR, a tapasin homolog, with MHC-I molecules promotes peptide editing. Proc Natl Acad Sci U S A 113:E1006-15
Montecinos-Franjola, Felipe; Schuck, Peter; Sackett, Dan L (2016) Tubulin Dimer Reversible Dissociation: AFFINITY, KINETICS, AND DEMONSTRATION OF A STABLE MONOMER. J Biol Chem 291:9281-94
Marzahn, Melissa R; Marada, Suresh; Lee, Jihun et al. (2016) Higher-order oligomerization promotes localization of SPOP to liquid nuclear speckles. EMBO J 35:1254-75
Schuck, Peter (2016) Sedimentation coefficient distributions of large particles. Analyst 141:4400-9

Showing the most recent 10 out of 39 publications