Abstract

The research of the new Molecular Biomedical Imaging Laboratory will include developing patient-based methods for detection and quantitative characterization of subclinical cardiovascular disease of the myocardium and blood vessels in both early phase clinical trials as well as in multi-center studies. Areas of study will include genetically determined disease, as well as acquired cardiovascular disease as a result of common risk factors. Methods include advanced magnetic resonance techniques, cardiovascular computed tomography, and molecular probes. A separate program directed towards optimization of MRI techniques for disease characterization and detection in body imaging was focused on breast cancer evaluation. This work is focused on detection of microcalcification with MRI, a marker of cancer. In addition, molecular motion of water in breast cancer is being evaluated using diffusion weighted imaging.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAEB000065-01
Application #
7967931
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2009
Total Cost
$1,000,000
Indirect Cost

  Institution

Name
National Institute of Biomedical Imaging and Bioengineering
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Dalal, Darshan; Tandri, Harikrishna; Judge, Daniel P et al. (2009) Morphologic variants of familial arrhythmogenic right ventricular dysplasia/cardiomyopathy a genetics-magnetic resonance imaging correlation study. J Am Coll Cardiol 53:1289-99
Jacobs, Michael A; Ouwerkerk, Ronald; Kamel, Ihab et al. (2009) Proton, diffusion-weighted imaging, and sodium (23Na) MRI of uterine leiomyomata after MR-guided high-intensity focused ultrasound: a preliminary study. J Magn Reson Imaging 29:649-56
Tops, Laurens F; Prakasa, Kalpana; Tandri, Harikrishna et al. (2009) Prevalence and pathophysiologic attributes of ventricular dyssynchrony in arrhythmogenic right ventricular dysplasia/cardiomyopathy. J Am Coll Cardiol 54:445-51
Duprez, Daniel A; Jacobs Jr, David R; Lutsey, Pamela L et al. (2009) Race/ethnic and sex differences in large and small artery elasticity--results of the multi-ethnic study of atherosclerosis (MESA). Ethn Dis 19:243-50
Rosen, Boaz D; Fernandes, Veronica R S; Nasir, Khuram et al. (2009) Age, increased left ventricular mass, and lower regional myocardial perfusion are related to greater extent of myocardial dyssynchrony in asymptomatic individuals: the multi-ethnic study of atherosclerosis. Circulation 120:859-66
Malayeri, Ashkan A; Macedo, Robson; Li, Debiao et al. (2009) Coronary vessel wall evaluation by magnetic resonance imaging in the multi-ethnic study of atherosclerosis: determinants of image quality. J Comput Assist Tomogr 33:1-7
Ding, Jingzhong; Hsu, Fang-Chi; Harris, Tamara B et al. (2009) The association of pericardial fat with incident coronary heart disease: the Multi-Ethnic Study of Atherosclerosis (MESA). Am J Clin Nutr 90:499-504
Liu, Longjian; Nettleton, Jennifer A; Bertoni, Alain G et al. (2009) Dietary pattern, the metabolic syndrome, and left ventricular mass and systolic function: the Multi-Ethnic Study of Atherosclerosis. Am J Clin Nutr 90:362-8
Tandri, Harikrishna; Asimaki, Angeliki; Abraham, Theodore et al. (2009) Prolonged RV endocardial activation duration: a novel marker of arrhythmogenic right ventricular dysplasia/cardiomyopathy. Heart Rhythm 6:769-75
Marcus, Frank I; Zareba, Wojciech; Calkins, Hugh et al. (2009) Arrhythmogenic right ventricular cardiomyopathy/dysplasia clinical presentation and diagnostic evaluation: results from the North American Multidisciplinary Study. Heart Rhythm 6:984-92

Showing the most recent 10 out of 24 publications