Genistein and daidzein are estrogenic isoflavones found in soybeans. Although they are much less potent than estradiol, infants fed soy formula have serum concentrations that are up to 4 orders of magnitude higher than estradiol. We have been in the field with a longitudinal study of infants up to 9 months old, looking in detail at the growth and development of their estrogen-responsive tissue as well as sex hormones and gonadotropins. We completed follow-up in May, 2014, and have begun data analysis. In addition, we reported this year the validation of a cytological method for asessing estrogen exposure in infants.

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14
Fiscal Year
2014
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Indirect Cost
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U.S. National Inst of Environ Hlth Scis
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Wang, Yan; Rogan, Walter J; Chen, Hsin-Yi et al. (2015) Prenatal exposure to perfluroalkyl substances and children's IQ: The Taiwan maternal and infant cohort study. Int J Hyg Environ Health 218:639-44
Adgent, Margaret A; Rogan, Walter J (2015) Triclosan and prescription antibiotic exposures and enterolactone production in adults. Environ Res 142:66-71
Wang, Yan; Cupul-Uicab, Lea A; Rogan, Walter J et al. (2015) Recreational Exercise Before and During Pregnancy in Relation to Plasma C-Reactive Protein Concentrations in Pregnant Women. J Phys Act Health 12:770-5
Liu, Jianghong; Liu, Xianchen; Wang, Wei et al. (2014) Blood lead concentrations and children's behavioral and emotional problems: a cohort study. JAMA Pediatr 168:737-45
Council on Environmental Health; Rogan, Walter J; Paulson, Jerome A et al. (2014) Iodine deficiency, pollutant chemicals, and the thyroid: new information on an old problem. Pediatrics 133:1163-6
Wang, Yan; Chen, Aimin; Dietrich, Kim N et al. (2014) Postnatal exposure to methyl mercury and neuropsychological development in 7-year-old urban inner-city children exposed to lead in the United States. Child Neuropsychol 20:527-38
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Adgent, Margaret A; Flake, Gordon P; Umbach, David M et al. (2013) Urogenital epithelial cells as simple markers of estrogen response in infants: methods and applications. PLoS One 8:e77061
Adgent, Margaret A; Daniels, Julie L; Rogan, Walter J et al. (2012) Early-life soy exposure and age at menarche. Paediatr Perinat Epidemiol 26:163-75
Valentín-Blasini, Liza; Blount, Benjamin C; Otero-Santos, Samaret et al. (2011) Perchlorate exposure and dose estimates in infants. Environ Sci Technol 45:4127-32

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