Abstract

Diet and other early exposures may affect child development and the risk of several chronic diseases, but additional research is needed. The current research described in this catch-all project comprises one project, described below. The weight of the placenta is often measured and may reflect the level of exposure of the fetus to certain hormones during gestation. In the report we published this year on this topic, we showed that placental weight was a useful indicator of estrogen exposure during pregnancy, an observation that will be of use in studies examining early-life risk factors for chronic diseases in adulthood. We also began work on a project examining physical activity during pregnancy in relation to neurodevelopment in offspring, based on data from the Avon Longitudinal Study of Parents and Children. As would be predicted on the basis of results in animal experiments, if the mother excercised during pregnancy the children's early language development was improved, independently of measured confounding factors. A draft manuscript is is preparation. Last years progress: 1 paper was published (see list below).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAES049021-15
Application #
8336559
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
15
Fiscal Year
2011
Total Cost
$57,479
Indirect Cost

  Institution

Name
National Institute of Environmental Health Sciences
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Trabert, Britton; Chodick, Gabriel; Shalev, Varda et al. (2014) Gestational diabetes and the risk of cryptorchidism and hypospadias. Epidemiology 25:152-3
Jensen, Elizabeth T; Longnecker, Matthew P (2014) Pharmacologic sex hormones in pregnancy in relation to offspring obesity. Obesity (Silver Spring) 22:2406-12
Mattsson, K; Källén, K; Longnecker, M P et al. (2013) Maternal smoking during pregnancy and daughters' risk of gestational diabetes and obesity. Diabetologia 56:1689-95
Jukic, Anne Marie Z; Lawlor, Debbie A; Juhl, Mette et al. (2013) Physical activity during pregnancy and language development in the offspring. Paediatr Perinat Epidemiol 27:283-93
Trabert, Britton; Longnecker, Matthew P; Graubard, Barry I et al. (2011) Placental characteristics as a proxy measure of serum hormone and protein levels during pregnancy with a male fetus. Cancer Causes Control 22:689-95
Eggesbø, Merete; Thomsen, Cathrine; Jørgensen, Jens V et al. (2011) Associations between brominated flame retardants in human milk and thyroid-stimulating hormone (TSH) in neonates. Environ Res 111:737-43
Baird, Donna Day; Saldana, Tina M; Nepomnaschy, Pablo A et al. (2010) Within-person variability in urinary phthalate metabolite concentrations: measurements from specimens after long-term frozen storage. J Expo Sci Environ Epidemiol 20:169-75
Basso, O; Pennell, M L; Chen, A et al. (2010) Mother's age at menarche and offspring size. Int J Obes (Lond) 34:1766-71
Ye, Xibiao; Qian, Haojun; Xu, Peicheng et al. (2009) Nephrotoxicity, neurotoxicity, and mercury exposure among children with and without dental amalgam fillings. Int J Hyg Environ Health 212:378-86
Nepomnaschy, Pablo A; Baird, Donna Day; Weinberg, Clarice R et al. (2009) Within-person variability in urinary bisphenol A concentrations: measurements from specimens after long-term frozen storage. Environ Res 109:734-7

Showing the most recent 10 out of 12 publications