Abstract

We explored the effect of pentabromodiphenyl ether (PBDE) exposure on Wistar Han rats pups on postnatal day 22. PBDE-47 is a congener of a PBDE mixture (DE-71) that was chosen as the test PBDE congener to compare PBDE-47 toxicity to the toxicity of DE-71. In utero and postnatal exposure was performed using chemical concentrations of 0, 0.1, 15, and 50 mg/kg by gavage. Both PBDE-47 and DE-71 exposure led to centrilobular hypertrophy and fatty change in liver and reduced serum thyroxin levels by PND 22. Liver transcriptomic changes included induced cytochrome p450 transcript levels and up-regulation of Nrf2 antioxidant pathway transcripts and up-regulation of ABC membrane transport transcripts. These transcriptional changes suggest that exposure to PBDE-47 and DE-71 could be a liver toxin or carcinogen after long-term exposure. A genomic benchmark dose concentration calculation showed that PBDE-47 exposure led to lower benchmark dose concentration than exposure to DE-71.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAES103166-07
Application #
10008731
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
7
Fiscal Year
2019
Total Cost
Indirect Cost

  Institution

Name
National Institute of Environmental Health Sciences
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Perron, Isaac J; Keenan, Brendan T; Chellappa, Karthikeyani et al. (2018) Dietary challenges differentially affect activity and sleep/wake behavior in mus musculus: Isolating independent associations with diet/energy balance and body weight. PLoS One 13:e0196743
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Hayes, Schantel A; Pandiri, Arun R; Ton, Thai-vu T et al. (2016) Renal Cell Carcinomas in Vinylidene Chloride-exposed Male B6C3F1 Mice Are Characterized by Oxidative Stress and TP53 Pathway Dysregulation. Toxicol Pathol 44:71-87
Blackshear, Pamela E; Pandiri, Arun R; Nagai, Hiroaki et al. (2015) Gene expression of mesothelioma in vinylidene chloride-exposed F344/N rats reveal immune dysfunction, tissue damage, and inflammation pathways. Toxicol Pathol 43:171-85
Bhusari, Sachin; Pandiri, Arun R; Nagai, Hiroaki et al. (2015) Genomic Profiling Reveals Unique Molecular Alterations in Hepatoblastomas and Adjacent Hepatocellular Carcinomas in B6C3F1 Mice. Toxicol Pathol 43:1114-26
George-Raizen, Julia B; Shockley, Keith R; Trojanowski, Nicholas F et al. (2014) Dynamically-expressed prion-like proteins form a cuticle in the pharynx of Caenorhabditis elegans. Biol Open 3:1139-49
Arnardottir, Erna S; Nikonova, Elena V; Shockley, Keith R et al. (2014) Blood-gene expression reveals reduced circadian rhythmicity in individuals resistant to sleep deprivation. Sleep 37:1589-600
Blackshear, Pamela E; Pandiri, Arun R; Ton, Thai-Vu T et al. (2014) Spontaneous mesotheliomas in F344/N rats are characterized by dysregulation of cellular growth and immune function pathways. Toxicol Pathol 42:863-76
Hoenerhoff, Mark J; Pandiri, Arun R; Snyder, Stephanie A et al. (2013) Hepatocellular carcinomas in B6C3F1 mice treated with Ginkgo biloba extract for two years differ from spontaneous liver tumors in cancer gene mutations and genomic pathways. Toxicol Pathol 41:826-41
Anafi, Ron C; Pellegrino, Renata; Shockley, Keith R et al. (2013) Sleep is not just for the brain: transcriptional responses to sleep in peripheral tissues. BMC Genomics 14:362

Showing the most recent 10 out of 12 publications