Integrated Health Assessments for the National Toxicology Program

Bucher, John

Abstract

The National Toxicology Program (NTP) is an interagency program whose mission is to evaluate agents of public health concern by developing and applying tools of modern toxicology and molecular biology. The programs goal is to carry out research, testing, and evaluation activities to identify which of the many thousands of chemicals and other substances that humans are exposed to in the environment may affect human health. To do so, the NTP must use scientific expertise to identify, collect, analyze, and interpret diverse types of information relevant to the effects of environmental exposures on human health. Information from the fields of toxicology, epidemiology, chemistry, pathology, and other disciplines is used in design of research programs and in literature-based health assessments for both cancer and non-cancer endpoints. The NTP information products include, among others, the congressionally mandated Report on Carcinogens (RoC), supporting listing monographs, and other related scientific review documents from the Office of Report on Carcinogens (ORoC); monographs, state-of-the-science documents, and workshop reports from the Office of Health Assessment and Translation (OHAT); as well as concept documents that communicate NTP plans for research studies or reviews, and protocols providing very detailed information about how a study or review will be undertaken.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Environmental Health Sciences (NIEHS)
• Type: Investigator-Initiated Intramural Research Projects (ZIA)
• Project #: 1ZIAES103317-02
• Application #: 9550222
• Support Year: 2
• Fiscal Year: 2017

Institution

• Name: U.S. National Inst of Environ Hlth Scis

Publications

Dorman, David C; Chiu, Weihsueh; Hales, Barbara F et al. (2018) Systematic reviews and meta-analyses of human and animal evidence of prenatal diethylhexyl phthalate exposure and changes in male anogenital distance. J Toxicol Environ Health B Crit Rev :1-20

Morgan, Rebecca L; Florez, Ivan; Falavigna, Maicon et al. (2018) Development of rapid guidelines: 3. GIN-McMaster Guideline Development Checklist extension for rapid recommendations. Health Res Policy Syst 16:63

Xia, Menghang; Huang, Ruili; Shi, Qiang et al. (2018) Comprehensive Analyses and Prioritization of Tox21 10K Chemicals Affecting Mitochondrial Function by in-Depth Mechanistic Studies. Environ Health Perspect 126:077010

Taylor, Kyla W; Troester, Melissa A; Herring, Amy H et al. (2018) Associations between Personal Care Product Use Patterns and Breast Cancer Risk among White and Black Women in the Sister Study. Environ Health Perspect 126:027011

Walker, Vickie R; Boyles, Abee L; Pelch, Katherine E et al. (2018) Human and animal evidence of potential transgenerational inheritance of health effects: An evidence map and state-of-the-science evaluation. Environ Int 115:48-69

Mason, Ivy C; Boubekri, Mohamed; Figueiro, Mariana G et al. (2018) Circadian Health and Light: A Report on the National Heart, Lung, and Blood Institute's Workshop. J Biol Rhythms 33:451-457

Hooijmans, Carlijn R; de Vries, Rob B M; Ritskes-Hoitinga, Merel et al. (2018) Facilitating healthcare decisions by assessing the certainty in the evidence from preclinical animal studies. PLoS One 13:e0187271

Lunn, Ruth M; Blask, David E; Coogan, Andrew N et al. (2017) Health consequences of electric lighting practices in the modern world: A report on the National Toxicology Program's workshop on shift work at night, artificial light at night, and circadian disruption. Sci Total Environ 607-608:1073-1084

Howdeshell, Kembra L; Hotchkiss, Andrew K; Gray Jr, L Earl (2017) Cumulative effects of antiandrogenic chemical mixtures and their relevance to human health risk assessment. Int J Hyg Environ Health 220:179-188

Germolec, Dori; Luebke, Robert; Rooney, Andrew et al. (2017) Immunotoxicology: A brief history, current status and strategies for future immunotoxicity assessment. Curr Opin Toxicol 5:55-59