Our study design enabled us to identify and follow 96 women consuming at least 4 drinks/day during pregnancy. In these women with heavy prenatal alcohol use, there were three stillbirths and one preterm delivery;98 matched nondrinking women had no stillbirths and two preterm births. Preterm rates did not differ significantly. The stillbirth rate was higher in the exposed group (p = 0.06). Additional investigation showed the stillbirth rate in the exposed population (3.1%) was significantly higher (p = 0.019) than the reported Chilean population rate (0.45%). Our data suggest that heavy alcohol consumption may increase the risk for stillbirth but not preterm delivery. Analysis is now complete and a report has been prepared describing the outcomes of the exposed children based on the amount and pattern of maternal alcohol consumption during pregnancy. The data will be reported soon.

Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
2011
Total Cost
$324,000
Indirect Cost
City
State
Country
Zip Code
Cornman-Homonoff, Joshua; Kuehn, Devon; Aros, SofĂ­a et al. (2012) Heavy prenatal alcohol exposure and risk of stillbirth and preterm delivery. J Matern Fetal Neonatal Med 25:860-3
Kuehn, Devon; Aros, Sofia; Cassorla, Fernando et al. (2012) A prospective cohort study of the prevalence of growth, facial, and central nervous system abnormalities in children with heavy prenatal alcohol exposure. Alcohol Clin Exp Res 36:1811-9
Aros, Sofia; Mills, James L; Iniguez, German et al. (2011) Effects of prenatal ethanol exposure on postnatal growth and the insulin-like growth factor axis. Horm Res Paediatr 75:166-73
Flanigan, Elizabeth Y; Aros, Sofia; Bueno, Maria Ferraz et al. (2008) Eye malformations in children with heavy alcohol exposure in utero. J Pediatr 153:391-5
Signore, Caroline; Aros, Sofia; Morrow, Jason D et al. (2008) Markers of oxidative stress and systemic vasoconstriction in pregnant women drinking >or =48 g of alcohol per day. Alcohol Clin Exp Res 32:1893-8