Cell-cell signaling is a major strategy that vertebrate embryos employ to control their development. We are interested in the mechanistic understanding of a major signaling pathway mediated by Wnts in the control of vertebrate embryonic development, in particular, limb development and skeletal morphogeneis. Early in limb development, signaling molecules which include the Wnt family members determine where and when the late structures, i.e., skeletal elements will form. Skeletal morphogeneis in the limb occurs through endochondral bone formation in which chondrocytes (they form the cartilage) and osteoblasts (they secrete bone matrix) are differentiated from mesenchymal condensations. This is followed by sequential proliferation and maturation of both chondrocytes and osteoblasts, which are tightly regulated and coordinated to ensure proper morphogenesis of the skeletal system. In the past year, we have being working on four aspects of the project: (1) The role of Wnt5a as a global cue in establishing chondrocyte polarity in the elongating cartilage. (2) The roles and mechanisms of Wnt/PCP in cartilage and bone development. (3) Wnt signaling regulates liver stem cell self renewal and differentiation. (4) The Wnt/Hippo signaling pathway in liver development and tumor formation.

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Human Genome Research
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Andre, Philipp; Song, Hai; Kim, Wantae et al. (2015) Wnt5a and Wnt11 regulate mammalian anterior-posterior axis elongation. Development 142:1516-27
Zhao, Haixia; Zhou, Wenrong; Yao, Zhengju et al. (2015) Foxp1/2/4 regulate endochondral ossification as a suppresser complex. Dev Biol 398:242-54
Qu, Yibo; Huang, Yuhua; Feng, Jia et al. (2014) Genetic evidence that Celsr3 and Celsr2, together with Fzd3, regulate forebrain wiring in a Vangl-independent manner. Proc Natl Acad Sci U S A 111:E2996-3004
Greer, Yoshimi Endo; Westlake, Christopher J; Gao, Bo et al. (2014) Casein kinase 1? functions at the centrosome and Golgi to promote ciliogenesis. Mol Biol Cell 25:1629-40
Pryor, Sophie E; Massa, Valentina; Savery, Dawn et al. (2014) Vangl-dependent planar cell polarity signalling is not required for neural crest migration in mammals. Development 141:3153-8
Boutin, Camille; Labedan, Paul; Dimidschstein, Jordane et al. (2014) A dual role for planar cell polarity genes in ciliated cells. Proc Natl Acad Sci U S A 111:E3129-38
Malhotra, Deepti; Yang, Yingzi (2014) Wnts' fashion statement: from body stature to dysplasia. Bonekey Rep 3:541
Regard, Jean B; Malhotra, Deepti; Gvozdenovic-Jeremic, Jelena et al. (2013) Activation of Hedgehog signaling by loss of GNAS causes heterotopic ossification. Nat Med 19:1505-12
Andre, Philipp; Yang, Yingzi (2013) Reply to Mazzeu: Human mutations in RYK might cause Robinow syndrome. J Biol Chem 288:2906
Gao, Bo; Yang, Yingzi (2013) Planar cell polarity in vertebrate limb morphogenesis. Curr Opin Genet Dev 23:438-44

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