Through our previous genomic studies using human blood and atherosclerotic plaque tissue samples, we identified a marker of atherosclerosis disease severity that was cholesterol-independent and statin treatment-dependent. This finding was granted a use patent. We have also identified tristetraprolin zinc finger protein 36 (TTP) as a mediator of localized tissue inflammation important for inflammatory arthritis and atherosclerosis. We are pursuing studies to examine how oxygen can affect disease processes such as atherosclerosis as well as examining mechanisms of chemotherapy-induced cardiomyopathy.

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Support Year
8
Fiscal Year
2017
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Indirect Cost
Name
U.S. National Heart Lung and Blood Inst
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Kang, Ju-Gyeong; Sung, Ho Joong; Amar, Marcelo J et al. (2016) Low ambient oxygen prevents atherosclerosis. J Mol Med (Berl) 94:277-86
Zhuang, Jie; Ma, Wenzhe; Lago, Cory U et al. (2012) Metabolic regulation of oxygen and redox homeostasis by p53: lessons from evolutionary biology? Free Radic Biol Med 53:1279-85
Kang, Ju-Gyeong; Amar, Marcelo J; Remaley, Alan T et al. (2011) Zinc finger protein tristetraprolin interacts with CCL3 mRNA and regulates tissue inflammation. J Immunol 187:2696-701
Kang, Ju-Gyeong; Sung, Ho Joong; Jawed, Sarah I et al. (2010) FOS expression in blood as a LDL-independent marker of statin treatment. Atherosclerosis 212:567-70
Biesecker, Leslie G; Mullikin, James C; Facio, Flavia M et al. (2009) The ClinSeq Project: piloting large-scale genome sequencing for research in genomic medicine. Genome Res 19:1665-74